Fibrillarin, a nucleolar protein, is required for normal nuclear morphology and cellular growth in HeLa cells

Fibrillarin is a key small nucleolar protein in eukaryotes, which has an important role in pre-rRNA processing during ribosomal biogenesis. Though several functions of fibrillarin are known, its function during the cell cycle is still unknown. In this study, we confirmed the dynamic localization of...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-08, Vol.360 (2), p.320-326
Hauptverfasser:	Amin, Mohammed Abdullahel, Matsunaga, Sachihiro, Ma, Nan, Takata, Hideaki, Yokoyama, Masami, Uchiyama, Susumu, Fukui, Kiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES CELL CYCLE Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Enlargement Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cell Proliferation Chromosomal Proteins, Non-Histone - metabolism DNA GROWTH HeLa cell HELA CELLS Humans MICROSCOPY MORPHOLOGY Nuclear morphology Nuclear Proteins - metabolism Nucleolar proteins PROTEINS RNA siRNA
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