siRNA targeting PLK-1 induces apoptosis of synoviocytes in rheumatoid arthritis

Polo-like kinase-1 (PLK-1) is a member of the PLK family and participates in the control of cell mitosis. Here, we show that immunoreactive PLK-1 is strongly expressed in synoviocytes and some infiltrative mononuclear cells in synovial tissues from patients with rheumatoid arthritis (RA), while pati...

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Veröffentlicht in:	Biochemical and biophysical research communications 2007-06, Vol.357 (2), p.353-359
Hauptverfasser:	Wada, Makoto, Kawahito, Yutaka, Kimura, Shinya, Kohno, Masataka, Ishino, Hidetaka, Kimura, Mizuho, Omoto, Atsushi, Yamamoto, Aihiro, Hamaguchi, Masahide, Tsubouchi, Yasunori, Tokunaga, Daisaku, Hojo, Tatsuya, Ashihara, Eishi, Maekawa, Taira, Yoshikawa, Toshikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSIS Apoptosis - genetics Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - physiopathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism CELL PROLIFERATION Cells, Cultured Gene Silencing Gene Targeting - methods Humans INJURIES MITOSIS PATIENTS PLK-1 Polo-Like Kinase 1 Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RADIOLOGY AND NUCLEAR MEDICINE RHEUMATIC DISEASES Rheumatoid arthritis RNA, Small Interfering - genetics siRNA SKELETON Synovial Fluid - cytology Synovial Fluid - metabolism Synoviocyte
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