Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells
Mesenchymal stem cells (MSCs) are attractive candidates for cell based therapies. However, the mechanisms responsible for stem cell migration and homing after transplantation remain unknown. It has been shown that insulin-like growth factor-1 (IGF-1) induces proliferation and migration of some cell...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2007-05, Vol.356 (3), p.780-784 |
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| creator | Li, Yangxin Yu, XiYong Lin, ShuGuang Li, XiaoHong Zhang, Saidan Song, Yao-Hua |
| description | Mesenchymal stem cells (MSCs) are attractive candidates for cell based therapies. However, the mechanisms responsible for stem cell migration and homing after transplantation remain unknown. It has been shown that insulin-like growth factor-1 (IGF-1) induces proliferation and migration of some cell types, but its effects on stem cells have not been investigated. We isolated and cultured MSC from rat bone marrow, and found that IGF-1 increased the expression levels of the chemokine receptor CXCR4 (receptor for stromal cell-derived factor-1, SDF-1). Moreover, IGF-1 markedly increased the migratory response of MSC to SDF-1. The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059. Our data indicate that IGF-1 increases MSC migratory responses via CXCR4 chemokine receptor signaling which is PI3/Akt dependent. These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies. |
| doi_str_mv | 10.1016/j.bbrc.2007.03.049 |
| format | Article |
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However, the mechanisms responsible for stem cell migration and homing after transplantation remain unknown. It has been shown that insulin-like growth factor-1 (IGF-1) induces proliferation and migration of some cell types, but its effects on stem cells have not been investigated. We isolated and cultured MSC from rat bone marrow, and found that IGF-1 increased the expression levels of the chemokine receptor CXCR4 (receptor for stromal cell-derived factor-1, SDF-1). Moreover, IGF-1 markedly increased the migratory response of MSC to SDF-1. The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059. Our data indicate that IGF-1 increases MSC migratory responses via CXCR4 chemokine receptor signaling which is PI3/Akt dependent. These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2007.03.049</identifier><identifier>PMID: 17382293</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; Androstadienes - pharmacology ; Animals ; BIOLOGICAL EFFECTS ; BONE MARROW ; Cell Movement - drug effects ; CELL PROLIFERATION ; Cell Proliferation - drug effects ; Chemokine CXCL12 ; Chemokines, CXC - physiology ; Chromones - pharmacology ; CXCR4 ; Flavonoids - pharmacology ; GROWTH FACTORS ; IGF-1 ; INSULIN ; Insulin-Like Growth Factor I - physiology ; Mesenchymal Stromal Cells - physiology ; Migration ; Morpholines - pharmacology ; Phosphatidylinositol 3-Kinases - antagonists & inhibitors ; RATS ; Rats, Inbred Lew ; RECEPTORS ; Receptors, CXCR4 - physiology ; SDF-1 ; Signal Transduction ; Stem cell ; STEM CELLS ; THERAPY</subject><ispartof>Biochemical and biophysical research communications, 2007-05, Vol.356 (3), p.780-784</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-a88cc07848b41bff344e8109c01be92e7287b54bf7488affb25b473e3429e7053</citedby><cites>FETCH-LOGICAL-c479t-a88cc07848b41bff344e8109c01be92e7287b54bf7488affb25b473e3429e7053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2007.03.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17382293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/20991338$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yangxin</creatorcontrib><creatorcontrib>Yu, XiYong</creatorcontrib><creatorcontrib>Lin, ShuGuang</creatorcontrib><creatorcontrib>Li, XiaoHong</creatorcontrib><creatorcontrib>Zhang, Saidan</creatorcontrib><creatorcontrib>Song, Yao-Hua</creatorcontrib><title>Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Mesenchymal stem cells (MSCs) are attractive candidates for cell based therapies. However, the mechanisms responsible for stem cell migration and homing after transplantation remain unknown. It has been shown that insulin-like growth factor-1 (IGF-1) induces proliferation and migration of some cell types, but its effects on stem cells have not been investigated. We isolated and cultured MSC from rat bone marrow, and found that IGF-1 increased the expression levels of the chemokine receptor CXCR4 (receptor for stromal cell-derived factor-1, SDF-1). Moreover, IGF-1 markedly increased the migratory response of MSC to SDF-1. The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059. Our data indicate that IGF-1 increases MSC migratory responses via CXCR4 chemokine receptor signaling which is PI3/Akt dependent. These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Androstadienes - pharmacology</subject><subject>Animals</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BONE MARROW</subject><subject>Cell Movement - drug effects</subject><subject>CELL PROLIFERATION</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemokine CXCL12</subject><subject>Chemokines, CXC - physiology</subject><subject>Chromones - pharmacology</subject><subject>CXCR4</subject><subject>Flavonoids - pharmacology</subject><subject>GROWTH FACTORS</subject><subject>IGF-1</subject><subject>INSULIN</subject><subject>Insulin-Like Growth Factor I - physiology</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Migration</subject><subject>Morpholines - pharmacology</subject><subject>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</subject><subject>RATS</subject><subject>Rats, Inbred Lew</subject><subject>RECEPTORS</subject><subject>Receptors, CXCR4 - physiology</subject><subject>SDF-1</subject><subject>Signal Transduction</subject><subject>Stem cell</subject><subject>STEM CELLS</subject><subject>THERAPY</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoO4uOPqH_AgAcFb91Y-ZpKAF1lWXVjwsoq3kGSqtzP2x5hkXObfm2YGvGldCoqnXuqtl5A3DFoGbHO9a71PoeUAqgXRgjTPyIqBgYYzkM_JCgA2DTfsxyV5mfMOgDG5MS_IJVNCc27Einy_m_JhiFMzxJ9IH9P8VHrauVDmRBnFqXdTwExLj3SMj8nV-ZEGt3chliOdOzpixin0x9ENNBccacBhyK_IReeGjK_P_Yp8-3T7cPOluf_6-e7m430TpDKlcVqHAEpL7SXzXSekRF0dBGAeDUfFtfJr6TsltXZd5_naSyVQSG5QwVpckXcn3TmXaHM9CkMf5mnCUCwHY5gQulLvT9Q-zb8OmIsdY17udBPOh2wVCKm5FP8FmamlQFWQn8CQ5pwTdnaf4ujS0TKwSzh2Z5dw7BKOBWFrOHXp7Vn94Efc_l05p1GBDycA68t-R0yLo_pd3Ma0GNrO8V_6fwDAl5-F</recordid><startdate>20070511</startdate><enddate>20070511</enddate><creator>Li, Yangxin</creator><creator>Yu, XiYong</creator><creator>Lin, ShuGuang</creator><creator>Li, XiaoHong</creator><creator>Zhang, Saidan</creator><creator>Song, Yao-Hua</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20070511</creationdate><title>Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells</title><author>Li, Yangxin ; Yu, XiYong ; Lin, ShuGuang ; Li, XiaoHong ; Zhang, Saidan ; Song, Yao-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-a88cc07848b41bff344e8109c01be92e7287b54bf7488affb25b473e3429e7053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>Androstadienes - pharmacology</topic><topic>Animals</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BONE MARROW</topic><topic>Cell Movement - drug effects</topic><topic>CELL PROLIFERATION</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemokine CXCL12</topic><topic>Chemokines, CXC - physiology</topic><topic>Chromones - pharmacology</topic><topic>CXCR4</topic><topic>Flavonoids - pharmacology</topic><topic>GROWTH FACTORS</topic><topic>IGF-1</topic><topic>INSULIN</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Mesenchymal Stromal Cells - physiology</topic><topic>Migration</topic><topic>Morpholines - pharmacology</topic><topic>Phosphatidylinositol 3-Kinases - antagonists & inhibitors</topic><topic>RATS</topic><topic>Rats, Inbred Lew</topic><topic>RECEPTORS</topic><topic>Receptors, CXCR4 - physiology</topic><topic>SDF-1</topic><topic>Signal Transduction</topic><topic>Stem cell</topic><topic>STEM CELLS</topic><topic>THERAPY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yangxin</creatorcontrib><creatorcontrib>Yu, XiYong</creatorcontrib><creatorcontrib>Lin, ShuGuang</creatorcontrib><creatorcontrib>Li, XiaoHong</creatorcontrib><creatorcontrib>Zhang, Saidan</creatorcontrib><creatorcontrib>Song, Yao-Hua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yangxin</au><au>Yu, XiYong</au><au>Lin, ShuGuang</au><au>Li, XiaoHong</au><au>Zhang, Saidan</au><au>Song, Yao-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2007-05-11</date><risdate>2007</risdate><volume>356</volume><issue>3</issue><spage>780</spage><epage>784</epage><pages>780-784</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Mesenchymal stem cells (MSCs) are attractive candidates for cell based therapies. However, the mechanisms responsible for stem cell migration and homing after transplantation remain unknown. It has been shown that insulin-like growth factor-1 (IGF-1) induces proliferation and migration of some cell types, but its effects on stem cells have not been investigated. We isolated and cultured MSC from rat bone marrow, and found that IGF-1 increased the expression levels of the chemokine receptor CXCR4 (receptor for stromal cell-derived factor-1, SDF-1). Moreover, IGF-1 markedly increased the migratory response of MSC to SDF-1. The IGF-1-induced increase in MSC migration in response to SDF-1 was attenuated by PI3 kinase inhibitor (LY294002 and wortmannin) but not by mitogen-activated protein/ERK kinase inhibitor PD98059. Our data indicate that IGF-1 increases MSC migratory responses via CXCR4 chemokine receptor signaling which is PI3/Akt dependent. These findings provide a new paradigm for biological effects of IGF-1 on MSC and have implications for the development of novel stem cell therapeutic strategies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17382293</pmid><doi>10.1016/j.bbrc.2007.03.049</doi><tpages>5</tpages></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES Androstadienes - pharmacology Animals BIOLOGICAL EFFECTS BONE MARROW Cell Movement - drug effects CELL PROLIFERATION Cell Proliferation - drug effects Chemokine CXCL12 Chemokines, CXC - physiology Chromones - pharmacology CXCR4 Flavonoids - pharmacology GROWTH FACTORS IGF-1 INSULIN Insulin-Like Growth Factor I - physiology Mesenchymal Stromal Cells - physiology Migration Morpholines - pharmacology Phosphatidylinositol 3-Kinases - antagonists & inhibitors RATS Rats, Inbred Lew RECEPTORS Receptors, CXCR4 - physiology SDF-1 Signal Transduction Stem cell STEM CELLS THERAPY |
| title | Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells |
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