Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis

The availability of highly toxic organophosphorus (OP) warfare agents (nerve agents) underlines the necessity for an effective medical treatment. Acute OP toxicity is primarily caused by inhibition of acetylcholinesterase (AChE). Reactivators (oximes) of inhibited AChE are a mainstay of treatment, h...

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Veröffentlicht in:	Toxicology and applied pharmacology 2007-03, Vol.219 (2), p.226-234
Hauptverfasser:	Worek, F., Eyer, P., Aurbek, N., Szinicz, L., Thiermann, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AChE AGING ANIMAL TISSUES ANIMALS Chemical Warfare Agents - chemistry Chemical Warfare Agents - poisoning Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - poisoning Cholinesterase Reactivators - chemistry Cholinesterase Reactivators - pharmacology Cholinesterase Reactivators - therapeutic use Computer model EVALUATION Humans IN VITRO In vitro studies In Vitro Techniques INHIBITION Molecular Structure Nerve agents Organophosphate Poisoning Organophosphorus Compounds - chemistry OXIMES Oximes - chemistry Oximes - pharmacology Oximes - therapeutic use PATIENTS PESTICIDES POISONING Poisoning - enzymology Poisoning - prevention & control Reactivation Species Specificity SYNTHESIS TOXICITY WARFARE
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