Phospholipase B activity and organophosphorus compound toxicity in cultured neural cells

Organophosphorus compounds (OP) such as phenyl saligenin phosphate (PSP) and mipafox (MPX) which cause delayed neuropathy, inhibit neuropathy target esterase (NTE), while OPs such as paraoxon (PXN) react more readily with acetylcholinesterase. In yeast and mammalian cell lines, NTE has been shown to...

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Veröffentlicht in:	Toxicology and applied pharmacology 2007-03, Vol.219 (2), p.190-195
Hauptverfasser:	Read, David J., Langford, Lynda, Barbour, Helen R., Forshaw, Philip J., Glynn, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Astrocyte Astrocytes - drug effects Astrocytes - enzymology Astrocytes - pathology CARBON 14 Cell Survival - drug effects Cells, Cultured Cerebellum - cytology Cerebral Cortex - cytology CHOLINE GANGLIONS GROWTH FACTORS IN VITRO LABELLING LECITHINS Lysophospholipase - metabolism MICE Mice, Inbred BALB C Mice, Inbred C57BL Molecular Structure MORPHOLOGY NERVE CELLS Neuron Neurons - drug effects Neurons - enzymology Neurons - pathology Organophosphate Organophosphorus Compounds - chemistry Organophosphorus Compounds - toxicity PHOSPHATES Phospholipase B ROOTS SERINE Serine hydrolase Structure-Activity Relationship TOXICITY YEASTS
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