Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy
Purpose: To compare the dose–volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. Methods and Materials: Between January 2004 and July 2005, 71 patients with International Federati...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2007-08, Vol.68 (5), p.1446-1454 |
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| creator | Koom, Woong Sub, M.D Sohn, Dae Kyung, M.D Kim, Joo-Young, M.D Kim, Jong Won, R.T.T Shin, Kyung Hwan, M.D Yoon, Sang Min, M.D Kim, Dae Yong, M.D Yoon, Myonggeun, Ph.D Shin, Dongho, Ph.D Park, Sung Yong, Ph.D Cho, Kwan Ho, M.D |
| description | Purpose: To compare the dose–volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. Methods and Materials: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB–IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRURP ) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (α/β = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. Results: The mean values of the DVH parameters and ICRURP were significantly greater in patients with a score of ≥2 than in those with a score |
| doi_str_mv | 10.1016/j.ijrobp.2007.02.009 |
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| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_20953603</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0360301607003112</els_id><sourcerecordid>20540225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-1e9f2230138228a9a382f1cc3b0c5f1528177184618e3ee09abba518fd8f8163</originalsourceid><addsrcrecordid>eNqFUsuO0zAUjRCIKQN_gJAlJHYpttM8ygJpmmGYkQbNaKYgdpbj3LQuiR1sp5Ad_8AfsuMvuFErIbFh4-c55x7de6LoOaNzRln2ejfXO2erfs4pzeeUzyldPohmrMiXcZKmnx9GM5pkNE4QfBI98X5HKWUsXzyOTnAteJ5ls-h3abt-CFCTte3sxsl-O8Yr6fHhUm-28bn1EN_JAOTKBCeV3Osg3UhWeN6OYQvIGEljHfkYwGkDpAS310q2pJRGgXtDbh20utNmop1DZ41HoaCtIbYhpXX4fbiuIHwDMGSq-evHz0-2HTogt9LJDlDcE2lqcgcqoPiHQVk_FdlKswFPbiqPddF1NZKLFr7rqgVyrzed1bX1yvbj0-hRI1sPz477abS-eLcuL-Prm_dX5dl1rNIFDTGDZcM5Ni0pOC_kUuLeMKWSiqq0YSkvWJ6zYpGxAhIAupRVJVNWNHXRFCxLTqOXB1nrgxZe6QBqq6wx6FtwukxxJgmiXh1QvbNfB_BBdNoraFtpwA4egWiG8xSBiwNQOeu9g0b0TnfYSsGomHIgduKQAzHlQFAuMAdIe3HUH6oO6r-k4-AR8PYAAGzFXoObrAIOrNZuclpb_b8K_wqoVptp8F9gBL-zgzPYZsGER4K4n7I4RZHmlCaM8eQPIi3gxg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20540225</pqid></control><display><type>article</type><title>Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Koom, Woong Sub, M.D ; Sohn, Dae Kyung, M.D ; Kim, Joo-Young, M.D ; Kim, Jong Won, R.T.T ; Shin, Kyung Hwan, M.D ; Yoon, Sang Min, M.D ; Kim, Dae Yong, M.D ; Yoon, Myonggeun, Ph.D ; Shin, Dongho, Ph.D ; Park, Sung Yong, Ph.D ; Cho, Kwan Ho, M.D</creator><creatorcontrib>Koom, Woong Sub, M.D ; Sohn, Dae Kyung, M.D ; Kim, Joo-Young, M.D ; Kim, Jong Won, R.T.T ; Shin, Kyung Hwan, M.D ; Yoon, Sang Min, M.D ; Kim, Dae Yong, M.D ; Yoon, Myonggeun, Ph.D ; Shin, Dongho, Ph.D ; Park, Sung Yong, Ph.D ; Cho, Kwan Ho, M.D</creatorcontrib><description>Purpose: To compare the dose–volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. Methods and Materials: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB–IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRURP ) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (α/β = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. Results: The mean values of the DVH parameters and ICRURP were significantly greater in patients with a score of ≥2 than in those with a score <2 at 12 months after RT (ICRURP , 71 Gyα/β3 vs. 66 Gyα/β3 , p = 0.02; D0.1cc , 93 Gyα/β3 vs. 85 Gyα/β3 , p = 0.04; D1cc , 80 Gyα/β3 vs. 73 Gyα/β3 , p = 0.02; D2cc , 75 Gyα/β3 vs. 69 Gyα/β3 , p = 0.02). The probability of a score of ≥2 showed a significant relationship with the DVH parameters and ICRURP (ICRURP , p = 0.03; D0.1cc , p = 0.05; D1cc , p = 0.02; D2cc , p = 0.02). Conclusion: Our preliminary data have shown that DVH values of the rectosigmoid colon obtained by computed tomography-based three-dimensional brachytherapy planning are reliable and predictive of score ≥2 rectosigmoid mucosal changes.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2007.02.009</identifier><identifier>PMID: 17482766</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenocarcinoma - radiotherapy ; Adult ; Aged ; BRACHYTHERAPY ; Brachytherapy - methods ; Carcinoma, Squamous Cell - radiotherapy ; CARCINOMAS ; Chi-Square Distribution ; Computed tomography-based brachytherapy ; COMPUTERIZED TOMOGRAPHY ; DOSE EQUIVALENTS ; DOSE RATES ; Dose-Response Relationship, Radiation ; Dose–volume parameters ; Female ; GYNECOLOGY ; Hematology, Oncology and Palliative Medicine ; Humans ; ICRU ; ICRU rectal point ; Intestinal Mucosa - pathology ; Intestinal Mucosa - radiation effects ; Middle Aged ; Mucosal change ; PATIENTS ; PLANNING ; Prospective Studies ; RADIATION DOSES ; Radiation Injuries - pathology ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; RECTUM ; Rectum - pathology ; Rectum - radiation effects ; Regression Analysis ; Sigmoidoscopy ; Tumor Burden ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>International journal of radiation oncology, biology, physics, 2007-08, Vol.68 (5), p.1446-1454</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-1e9f2230138228a9a382f1cc3b0c5f1528177184618e3ee09abba518fd8f8163</citedby><cites>FETCH-LOGICAL-c540t-1e9f2230138228a9a382f1cc3b0c5f1528177184618e3ee09abba518fd8f8163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301607003112$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17482766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/20953603$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Koom, Woong Sub, M.D</creatorcontrib><creatorcontrib>Sohn, Dae Kyung, M.D</creatorcontrib><creatorcontrib>Kim, Joo-Young, M.D</creatorcontrib><creatorcontrib>Kim, Jong Won, R.T.T</creatorcontrib><creatorcontrib>Shin, Kyung Hwan, M.D</creatorcontrib><creatorcontrib>Yoon, Sang Min, M.D</creatorcontrib><creatorcontrib>Kim, Dae Yong, M.D</creatorcontrib><creatorcontrib>Yoon, Myonggeun, Ph.D</creatorcontrib><creatorcontrib>Shin, Dongho, Ph.D</creatorcontrib><creatorcontrib>Park, Sung Yong, Ph.D</creatorcontrib><creatorcontrib>Cho, Kwan Ho, M.D</creatorcontrib><title>Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose: To compare the dose–volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. Methods and Materials: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB–IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRURP ) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (α/β = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. Results: The mean values of the DVH parameters and ICRURP were significantly greater in patients with a score of ≥2 than in those with a score <2 at 12 months after RT (ICRURP , 71 Gyα/β3 vs. 66 Gyα/β3 , p = 0.02; D0.1cc , 93 Gyα/β3 vs. 85 Gyα/β3 , p = 0.04; D1cc , 80 Gyα/β3 vs. 73 Gyα/β3 , p = 0.02; D2cc , 75 Gyα/β3 vs. 69 Gyα/β3 , p = 0.02). The probability of a score of ≥2 showed a significant relationship with the DVH parameters and ICRURP (ICRURP , p = 0.03; D0.1cc , p = 0.05; D1cc , p = 0.02; D2cc , p = 0.02). Conclusion: Our preliminary data have shown that DVH values of the rectosigmoid colon obtained by computed tomography-based three-dimensional brachytherapy planning are reliable and predictive of score ≥2 rectosigmoid mucosal changes.</description><subject>Adenocarcinoma - radiotherapy</subject><subject>Adult</subject><subject>Aged</subject><subject>BRACHYTHERAPY</subject><subject>Brachytherapy - methods</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>CARCINOMAS</subject><subject>Chi-Square Distribution</subject><subject>Computed tomography-based brachytherapy</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>DOSE EQUIVALENTS</subject><subject>DOSE RATES</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Dose–volume parameters</subject><subject>Female</subject><subject>GYNECOLOGY</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>ICRU</subject><subject>ICRU rectal point</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - radiation effects</subject><subject>Middle Aged</subject><subject>Mucosal change</subject><subject>PATIENTS</subject><subject>PLANNING</subject><subject>Prospective Studies</subject><subject>RADIATION DOSES</subject><subject>Radiation Injuries - pathology</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>RECTUM</subject><subject>Rectum - pathology</subject><subject>Rectum - radiation effects</subject><subject>Regression Analysis</subject><subject>Sigmoidoscopy</subject><subject>Tumor Burden</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO0zAUjRCIKQN_gJAlJHYpttM8ygJpmmGYkQbNaKYgdpbj3LQuiR1sp5Ad_8AfsuMvuFErIbFh4-c55x7de6LoOaNzRln2ejfXO2erfs4pzeeUzyldPohmrMiXcZKmnx9GM5pkNE4QfBI98X5HKWUsXzyOTnAteJ5ls-h3abt-CFCTte3sxsl-O8Yr6fHhUm-28bn1EN_JAOTKBCeV3Osg3UhWeN6OYQvIGEljHfkYwGkDpAS310q2pJRGgXtDbh20utNmop1DZ41HoaCtIbYhpXX4fbiuIHwDMGSq-evHz0-2HTogt9LJDlDcE2lqcgcqoPiHQVk_FdlKswFPbiqPddF1NZKLFr7rqgVyrzed1bX1yvbj0-hRI1sPz477abS-eLcuL-Prm_dX5dl1rNIFDTGDZcM5Ni0pOC_kUuLeMKWSiqq0YSkvWJ6zYpGxAhIAupRVJVNWNHXRFCxLTqOXB1nrgxZe6QBqq6wx6FtwukxxJgmiXh1QvbNfB_BBdNoraFtpwA4egWiG8xSBiwNQOeu9g0b0TnfYSsGomHIgduKQAzHlQFAuMAdIe3HUH6oO6r-k4-AR8PYAAGzFXoObrAIOrNZuclpb_b8K_wqoVptp8F9gBL-zgzPYZsGER4K4n7I4RZHmlCaM8eQPIi3gxg</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Koom, Woong Sub, M.D</creator><creator>Sohn, Dae Kyung, M.D</creator><creator>Kim, Joo-Young, M.D</creator><creator>Kim, Jong Won, R.T.T</creator><creator>Shin, Kyung Hwan, M.D</creator><creator>Yoon, Sang Min, M.D</creator><creator>Kim, Dae Yong, M.D</creator><creator>Yoon, Myonggeun, Ph.D</creator><creator>Shin, Dongho, Ph.D</creator><creator>Park, Sung Yong, Ph.D</creator><creator>Cho, Kwan Ho, M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>OTOTI</scope></search><sort><creationdate>20070801</creationdate><title>Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy</title><author>Koom, Woong Sub, M.D ; Sohn, Dae Kyung, M.D ; Kim, Joo-Young, M.D ; Kim, Jong Won, R.T.T ; Shin, Kyung Hwan, M.D ; Yoon, Sang Min, M.D ; Kim, Dae Yong, M.D ; Yoon, Myonggeun, Ph.D ; Shin, Dongho, Ph.D ; Park, Sung Yong, Ph.D ; Cho, Kwan Ho, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-1e9f2230138228a9a382f1cc3b0c5f1528177184618e3ee09abba518fd8f8163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenocarcinoma - radiotherapy</topic><topic>Adult</topic><topic>Aged</topic><topic>BRACHYTHERAPY</topic><topic>Brachytherapy - methods</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>CARCINOMAS</topic><topic>Chi-Square Distribution</topic><topic>Computed tomography-based brachytherapy</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>DOSE EQUIVALENTS</topic><topic>DOSE RATES</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Dose–volume parameters</topic><topic>Female</topic><topic>GYNECOLOGY</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>ICRU</topic><topic>ICRU rectal point</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - radiation effects</topic><topic>Middle Aged</topic><topic>Mucosal change</topic><topic>PATIENTS</topic><topic>PLANNING</topic><topic>Prospective Studies</topic><topic>RADIATION DOSES</topic><topic>Radiation Injuries - pathology</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>RECTUM</topic><topic>Rectum - pathology</topic><topic>Rectum - radiation effects</topic><topic>Regression Analysis</topic><topic>Sigmoidoscopy</topic><topic>Tumor Burden</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koom, Woong Sub, M.D</creatorcontrib><creatorcontrib>Sohn, Dae Kyung, M.D</creatorcontrib><creatorcontrib>Kim, Joo-Young, M.D</creatorcontrib><creatorcontrib>Kim, Jong Won, R.T.T</creatorcontrib><creatorcontrib>Shin, Kyung Hwan, M.D</creatorcontrib><creatorcontrib>Yoon, Sang Min, M.D</creatorcontrib><creatorcontrib>Kim, Dae Yong, M.D</creatorcontrib><creatorcontrib>Yoon, Myonggeun, Ph.D</creatorcontrib><creatorcontrib>Shin, Dongho, Ph.D</creatorcontrib><creatorcontrib>Park, Sung Yong, Ph.D</creatorcontrib><creatorcontrib>Cho, Kwan Ho, M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koom, Woong Sub, M.D</au><au>Sohn, Dae Kyung, M.D</au><au>Kim, Joo-Young, M.D</au><au>Kim, Jong Won, R.T.T</au><au>Shin, Kyung Hwan, M.D</au><au>Yoon, Sang Min, M.D</au><au>Kim, Dae Yong, M.D</au><au>Yoon, Myonggeun, Ph.D</au><au>Shin, Dongho, Ph.D</au><au>Park, Sung Yong, Ph.D</au><au>Cho, Kwan Ho, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>68</volume><issue>5</issue><spage>1446</spage><epage>1454</epage><pages>1446-1454</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose: To compare the dose–volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. Methods and Materials: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB–IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRURP ) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (α/β = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. Results: The mean values of the DVH parameters and ICRURP were significantly greater in patients with a score of ≥2 than in those with a score <2 at 12 months after RT (ICRURP , 71 Gyα/β3 vs. 66 Gyα/β3 , p = 0.02; D0.1cc , 93 Gyα/β3 vs. 85 Gyα/β3 , p = 0.04; D1cc , 80 Gyα/β3 vs. 73 Gyα/β3 , p = 0.02; D2cc , 75 Gyα/β3 vs. 69 Gyα/β3 , p = 0.02). The probability of a score of ≥2 showed a significant relationship with the DVH parameters and ICRURP (ICRURP , p = 0.03; D0.1cc , p = 0.05; D1cc , p = 0.02; D2cc , p = 0.02). Conclusion: Our preliminary data have shown that DVH values of the rectosigmoid colon obtained by computed tomography-based three-dimensional brachytherapy planning are reliable and predictive of score ≥2 rectosigmoid mucosal changes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17482766</pmid><doi>10.1016/j.ijrobp.2007.02.009</doi><tpages>9</tpages></addata></record> |
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| ispartof | International journal of radiation oncology, biology, physics, 2007-08, Vol.68 (5), p.1446-1454 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| subjects | Adenocarcinoma - radiotherapy Adult Aged BRACHYTHERAPY Brachytherapy - methods Carcinoma, Squamous Cell - radiotherapy CARCINOMAS Chi-Square Distribution Computed tomography-based brachytherapy COMPUTERIZED TOMOGRAPHY DOSE EQUIVALENTS DOSE RATES Dose-Response Relationship, Radiation Dose–volume parameters Female GYNECOLOGY Hematology, Oncology and Palliative Medicine Humans ICRU ICRU rectal point Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Middle Aged Mucosal change PATIENTS PLANNING Prospective Studies RADIATION DOSES Radiation Injuries - pathology Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods RECTUM Rectum - pathology Rectum - radiation effects Regression Analysis Sigmoidoscopy Tumor Burden Uterine Cervical Neoplasms - radiotherapy |
| title | Computed Tomography-Based High-Dose-Rate Intracavitary Brachytherapy for Uterine Cervical Cancer: Preliminary Demonstration of Correlation Between Dose–Volume Parameters and Rectal Mucosal Changes Observed by Flexible Sigmoidoscopy |
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