Proton momentum distribution in a protein hydration shell
The momentum distribution of protons in the hydration shell of a globular protein has been measured through deep inelastic neutron scattering at 180 and 290 K, below and above the crossover temperature Tc=1.23Tg, where Tg=219 K is the glass transition temperature. It is found that the mean kinetic e...
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| Veröffentlicht in: | Physical review letters 2007-03, Vol.98 (13), p.138102-138102, Article 138102 |
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| container_end_page | 138102 |
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| container_issue | 13 |
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| container_title | Physical review letters |
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| creator | Senesi, R Pietropaolo, A Bocedi, A Pagnotta, S E Bruni, F |
| description | The momentum distribution of protons in the hydration shell of a globular protein has been measured through deep inelastic neutron scattering at 180 and 290 K, below and above the crossover temperature Tc=1.23Tg, where Tg=219 K is the glass transition temperature. It is found that the mean kinetic energy of the water hydrogens shows no temperature dependence, but the measurements are accurate enough to indicate a sensible change of momentum distribution and effective potential felt by protons, compatible with the transition from a single to a double potential well. This could support the presence of tunneling effects even at room temperature, playing an important role in biological function. |
| doi_str_mv | 10.1103/PhysRevLett.98.138102 |
| format | Article |
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It is found that the mean kinetic energy of the water hydrogens shows no temperature dependence, but the measurements are accurate enough to indicate a sensible change of momentum distribution and effective potential felt by protons, compatible with the transition from a single to a double potential well. This could support the presence of tunneling effects even at room temperature, playing an important role in biological function.</description><subject>Algorithms</subject><subject>DEEP INELASTIC SCATTERING</subject><subject>GLASS</subject><subject>HYDRATION</subject><subject>HYDROGEN</subject><subject>KINETIC ENERGY</subject><subject>MATERIALS SCIENCE</subject><subject>NEUTRON DIFFRACTION</subject><subject>Neutrons</subject><subject>POTENTIALS</subject><subject>PROTEINS</subject><subject>Proteins - chemistry</subject><subject>PROTONS</subject><subject>Scattering, Radiation</subject><subject>Temperature</subject><subject>TEMPERATURE DEPENDENCE</subject><subject>TEMPERATURE RANGE 0065-0273 K</subject><subject>TEMPERATURE RANGE 0273-0400 K</subject><subject>TRANSITION TEMPERATURE</subject><subject>TUNNEL EFFECT</subject><subject>WATER</subject><subject>Water - chemistry</subject><issn>0031-9007</issn><issn>1079-7114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF9LwzAUxYMobk4_glIQfOvMbZImeRTxHwwcos8hTVIaWdvZpMK-vZkd6NM9XH7n3sNB6BLwEgCT23WzC2_ue-ViXEqxBCIAF0doDpjLnAPQYzTHmEAuMeYzdBbCJ8YYilKcohlwliQt5kiuhz72Xdb2revi2GbWhzj4aow-bX2X6WybCJdUs7OD_l2Hxm025-ik1pvgLg5zgT4eH97vn_PV69PL_d0qN0QUMXesYpbXZUWJrEQpRKmtZJg7XDDitJZ1qQ3hVNMCCNPMsAostWBLWmvhOFmg6-luH6JXwfjoTGP6rnMmqgJLBiD31M1EpbRfowtRtT6YFFN3rh-D4jj9BCoSyCbQDH0Ig6vVdvCtHnYKsNo3q_41q6RQU7PJd3V4MFats3-uQ5XkB2jbdzE</recordid><startdate>20070330</startdate><enddate>20070330</enddate><creator>Senesi, R</creator><creator>Pietropaolo, A</creator><creator>Bocedi, A</creator><creator>Pagnotta, S E</creator><creator>Bruni, F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20070330</creationdate><title>Proton momentum distribution in a protein hydration shell</title><author>Senesi, R ; Pietropaolo, A ; Bocedi, A ; Pagnotta, S E ; Bruni, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-e5b5d7f6b439b86886ad9507e0253eaa9f6ac374a42135a5c5b1d4d1d64fa8e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Algorithms</topic><topic>DEEP INELASTIC SCATTERING</topic><topic>GLASS</topic><topic>HYDRATION</topic><topic>HYDROGEN</topic><topic>KINETIC ENERGY</topic><topic>MATERIALS SCIENCE</topic><topic>NEUTRON DIFFRACTION</topic><topic>Neutrons</topic><topic>POTENTIALS</topic><topic>PROTEINS</topic><topic>Proteins - chemistry</topic><topic>PROTONS</topic><topic>Scattering, Radiation</topic><topic>Temperature</topic><topic>TEMPERATURE DEPENDENCE</topic><topic>TEMPERATURE RANGE 0065-0273 K</topic><topic>TEMPERATURE RANGE 0273-0400 K</topic><topic>TRANSITION TEMPERATURE</topic><topic>TUNNEL EFFECT</topic><topic>WATER</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senesi, R</creatorcontrib><creatorcontrib>Pietropaolo, A</creatorcontrib><creatorcontrib>Bocedi, A</creatorcontrib><creatorcontrib>Pagnotta, S E</creatorcontrib><creatorcontrib>Bruni, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Physical review letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senesi, R</au><au>Pietropaolo, A</au><au>Bocedi, A</au><au>Pagnotta, S E</au><au>Bruni, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton momentum distribution in a protein hydration shell</atitle><jtitle>Physical review letters</jtitle><addtitle>Phys Rev Lett</addtitle><date>2007-03-30</date><risdate>2007</risdate><volume>98</volume><issue>13</issue><spage>138102</spage><epage>138102</epage><pages>138102-138102</pages><artnum>138102</artnum><issn>0031-9007</issn><eissn>1079-7114</eissn><abstract>The momentum distribution of protons in the hydration shell of a globular protein has been measured through deep inelastic neutron scattering at 180 and 290 K, below and above the crossover temperature Tc=1.23Tg, where Tg=219 K is the glass transition temperature. It is found that the mean kinetic energy of the water hydrogens shows no temperature dependence, but the measurements are accurate enough to indicate a sensible change of momentum distribution and effective potential felt by protons, compatible with the transition from a single to a double potential well. This could support the presence of tunneling effects even at room temperature, playing an important role in biological function.</abstract><cop>United States</cop><pmid>17501242</pmid><doi>10.1103/PhysRevLett.98.138102</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Physical review letters, 2007-03, Vol.98 (13), p.138102-138102, Article 138102 |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Algorithms DEEP INELASTIC SCATTERING GLASS HYDRATION HYDROGEN KINETIC ENERGY MATERIALS SCIENCE NEUTRON DIFFRACTION Neutrons POTENTIALS PROTEINS Proteins - chemistry PROTONS Scattering, Radiation Temperature TEMPERATURE DEPENDENCE TEMPERATURE RANGE 0065-0273 K TEMPERATURE RANGE 0273-0400 K TRANSITION TEMPERATURE TUNNEL EFFECT WATER Water - chemistry |
| title | Proton momentum distribution in a protein hydration shell |
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