Pairing of heterochromatin in response to cellular stress

We previously reported that exposure of human cells to DNA-damaging agents (X-rays and mitomycin C (MMC)) induces pairing of the homologous paracentromeric heterochromatin of chromosome 9 (9q12–13). Here, we show that UV irradiation and also heat shock treatment of human cells lead to similar effect...

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Veröffentlicht in:	Experimental cell research 2006-07, Vol.312 (11), p.1961-1969
Hauptverfasser:	Abdel-Halim, H.I., Mullenders, L.H.F., Boei, J.J.W.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AFTER-HEAT Cells Cells, Cultured Cellular stress Chromosome pairing Chromosome Pairing - genetics Chromosome Pairing - radiation effects CHROMOSOMES Chromosomes - physiology Chromosomes - radiation effects CONGENITAL DISEASES DNA damage DNA Damage - physiology DNA DAMAGES DNA REPAIR Fibroblasts - physiology Fibroblasts - radiation effects HEAT Heat shock Heat-Shock Response HEREDITARY DISEASES HETEROCHROMATIN Heterochromatin - physiology Heterochromatin - radiation effects Humans Interphase - radiation effects IRRADIATION MITOMYCIN Radiation RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS SKIN DISEASES Stress ULTRAVIOLET RADIATION Ultraviolet Rays UV radiation X RADIATION Xeroderma pigmentosum Xeroderma Pigmentosum - genetics XP CELLS
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