High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes
Low circulating levels of high molecular weight adiponectin (HMW-Apm) have been linked to dyslipidaemia and systemic HMW-Apm negatively correlates with very low density lipoprotein (VLDL), apolipoprotein B (ApoB), and ApoE and is positively associated with ApoA-I. Therefore, it was investigated whet...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2007-01, Vol.352 (2), p.543-548 |
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| creator | Neumeier, Markus Sigruener, Alexander Eggenhofer, Elke Weigert, Johanna Weiss, Thomas S. Schaeffler, Andreas Schlitt, Hans J. Aslanidis, Charalampos Piso, Pompiliu Langmann, Thomas Schmitz, Gerd Schölmerich, Jürgen Buechler, Christa |
| description | Low circulating levels of high molecular weight adiponectin (HMW-Apm) have been linked to dyslipidaemia and systemic HMW-Apm negatively correlates with very low density lipoprotein (VLDL), apolipoprotein B (ApoB), and ApoE and is positively associated with ApoA-I. Therefore, it was investigated whether HMW-Apm alters the hepatic synthesis of ApoB, ApoE, and ApoA-I or the activity of the hepatic ATP-binding cassette transporter A1 (ABCA1), as the main determinant of plasma HDL. HMW-Apm reduces hepatic ApoB and ApoE release whereas ABCA1 protein, activity and ApoA-I were not altered. Global gene expression analysis revealed that hepatic nuclear factor 4-α (HNF4-α) and HNF4-α regulated genes like ApoB are downregulated by HMW-Apm and this was confirmed at the mRNA and protein level. Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced. |
| doi_str_mv | 10.1016/j.bbrc.2006.11.058 |
| format | Article |
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Therefore, it was investigated whether HMW-Apm alters the hepatic synthesis of ApoB, ApoE, and ApoA-I or the activity of the hepatic ATP-binding cassette transporter A1 (ABCA1), as the main determinant of plasma HDL. HMW-Apm reduces hepatic ApoB and ApoE release whereas ABCA1 protein, activity and ApoA-I were not altered. Global gene expression analysis revealed that hepatic nuclear factor 4-α (HNF4-α) and HNF4-α regulated genes like ApoB are downregulated by HMW-Apm and this was confirmed at the mRNA and protein level. 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Therefore, it was investigated whether HMW-Apm alters the hepatic synthesis of ApoB, ApoE, and ApoA-I or the activity of the hepatic ATP-binding cassette transporter A1 (ABCA1), as the main determinant of plasma HDL. HMW-Apm reduces hepatic ApoB and ApoE release whereas ABCA1 protein, activity and ApoA-I were not altered. Global gene expression analysis revealed that hepatic nuclear factor 4-α (HNF4-α) and HNF4-α regulated genes like ApoB are downregulated by HMW-Apm and this was confirmed at the mRNA and protein level. Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Adiponectin</subject><subject>Adiponectin - administration & dosage</subject><subject>Adiponectin - chemistry</subject><subject>Apolipoprotein B</subject><subject>Apolipoproteins B - metabolism</subject><subject>Apolipoproteins E - metabolism</subject><subject>ATP</subject><subject>ATP-binding cassette transporter A1</subject><subject>BIOSYNTHESIS</subject><subject>Cells, Cultured</subject><subject>Dyslipidaemia</subject><subject>GENES</subject><subject>Hepatic nuclear factor 4-α</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Humans</subject><subject>LIPOPROTEINS</subject><subject>LIVER</subject><subject>LIVER CELLS</subject><subject>MOLECULAR WEIGHT</subject><subject>SECRETION</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF-L1TAQxYMo7nX1C_ggBcG31kzSNi34osvqCgu-KPgiIX8m3lzapiapst_elHvBN18y5MyZw8yPkJdAG6DQvz01WkfTMEr7BqCh3fCIHICOtGZA28fkQEunZiN8vyLPUjpRCtD241NyBQLY2InuQH7c-Z_Hag4Tmm1SsfqD5Z8rZf0aFjTZL1VEuxlMlVrDVNQ1hoxF_lCpxVa3pT2hSlgV6bjNqry4qhzMQ8b0nDxxakr44lKvybePt19v7ur7L58-37y_r03bDrkWnGntjGs7J3onBLd2BIEWFDfaOMV1p8Vg3MA6ptRAez4oEExwA7p1pufX5PU5N6TsZTI-ozmasOwXSEaHTow9La43Z1c54deGKcvZJ4PTpBYMW5L9wAVvWyhGdjaaGFKK6OQa_azigwQqd_TyJHf0ckcvAWRBX4ZeXdI3PaP9N3JhXQzvzgYsJH57jPuiuBi0Pu572uD_l_8X3DSV3g</recordid><startdate>20070112</startdate><enddate>20070112</enddate><creator>Neumeier, Markus</creator><creator>Sigruener, Alexander</creator><creator>Eggenhofer, Elke</creator><creator>Weigert, Johanna</creator><creator>Weiss, Thomas S.</creator><creator>Schaeffler, Andreas</creator><creator>Schlitt, Hans J.</creator><creator>Aslanidis, Charalampos</creator><creator>Piso, Pompiliu</creator><creator>Langmann, Thomas</creator><creator>Schmitz, Gerd</creator><creator>Schölmerich, Jürgen</creator><creator>Buechler, Christa</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20070112</creationdate><title>High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes</title><author>Neumeier, Markus ; 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Therefore, it was investigated whether HMW-Apm alters the hepatic synthesis of ApoB, ApoE, and ApoA-I or the activity of the hepatic ATP-binding cassette transporter A1 (ABCA1), as the main determinant of plasma HDL. HMW-Apm reduces hepatic ApoB and ApoE release whereas ABCA1 protein, activity and ApoA-I were not altered. Global gene expression analysis revealed that hepatic nuclear factor 4-α (HNF4-α) and HNF4-α regulated genes like ApoB are downregulated by HMW-Apm and this was confirmed at the mRNA and protein level. Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17129575</pmid><doi>10.1016/j.bbrc.2006.11.058</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2007-01, Vol.352 (2), p.543-548 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 60 APPLIED LIFE SCIENCES Adiponectin Adiponectin - administration & dosage Adiponectin - chemistry Apolipoprotein B Apolipoproteins B - metabolism Apolipoproteins E - metabolism ATP ATP-binding cassette transporter A1 BIOSYNTHESIS Cells, Cultured Dyslipidaemia GENES Hepatic nuclear factor 4-α Hepatocytes - drug effects Hepatocytes - metabolism Humans LIPOPROTEINS LIVER LIVER CELLS MOLECULAR WEIGHT SECRETION |
| title | High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes |
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