Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats—Correlation of HSP72 expression with mucosal protection

The real mechanism of adaptive cytoprotection in the gastric mucosa is not well established. In the present study, we investigated the effect of acid suppressing agents on a 72-kDa heat shock protein (HSP72) expression, which is known as endogenous cytoprotective factor, in the gastric mucosa. Also,...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-10, Vol.349 (2), p.611-618
Hauptverfasser:	Wada, Isao, Otaka, Michiro, Jin, Mario, Odashima, Masaru, Komatsu, Koga, Konishi, Noriaki, Matsuhashi, Tamotsu, Horikawa, Youhei, Ohba, Reina, Itoh, Hideaki, Watanabe, Sumio
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adaptation Animals Anti-Ulcer Agents - pharmacology Carnosine - analogs & derivatives Carnosine - chemistry Famotidine - pharmacology GASTRIC ACID Gastric Acid - metabolism Gastric Mucosa - metabolism Gene Expression Regulation Heat shock protein HEAT-SHOCK PROTEINS HSP HSP72 Heat-Shock Proteins - biosynthesis HYDROCHLORIC ACID Hydrochloric Acid - pharmacology Hydrogen-Ion Concentration Male Mucous Membrane - metabolism MUCOUS MEMBRANES Omeprazole - pharmacology Organometallic Compounds - chemistry PROTONS RATS Rats, Sprague-Dawley RECEPTORS Stomach Stomach - metabolism ZINC Zinc Compounds Zinc Sulfate - chemistry ZINC SULFATES
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