A novel p53-binding domain in CUL7

CUL7 is a member of the cullin RING ligase family and forms an SCF-like complex with SKP1 and FBXW8. CUL7 is required for normal mouse embryonic development and cellular proliferation, and is highly homologous to PARC, a p53-associated, parkin-like cytoplasmic protein. We determined that CUL7, in a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-09, Vol.348 (1), p.132-138
Hauptverfasser:	Kasper, Jocelyn S., Arai, Takehiro, DeCaprio, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Binding Sites Carrier Proteins - genetics Cell Line, Tumor CELL PROLIFERATION Cells, Cultured CUL7 Cullin Proteins - chemistry Cullin Proteins - genetics Cullin Proteins - metabolism Cullin RING ligase GENE REGULATION Humans LIGASES MICE NEOPLASMS ONTOGENESIS p53 PARC Protein Binding Protein Structure, Tertiary - genetics Sequence Homology SKP-cullin-F box Tumor Suppressor Protein p53 - metabolism Tumor suppressors Ubiquitin-protein ligases Ubiquitin-Protein Ligases - genetics
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