Contribution of the 37-kDa laminin receptor precursor in the anti-metastatic PSP94-derived peptide PCK3145 cell surface binding

PCK3145 is an anti-metastatic synthetic peptide with promising therapeutic efficacy against hormone-refractory prostate cancer. The characterization of the PCK3145 peptide cell surface binding/internalization mechanisms and of the receptors involved remained to be explored. [ 14C]PCK3145 cell surfac...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-07, Vol.346 (1), p.358-366
Hauptverfasser:	Annabi, Borhane, Currie, Jean-Christophe, Bouzeghrane, Mounia, Dulude, Hélène, Daigneault, Luc, Garde, Seema, Rabbani, Shafaat A., Panchal, Chandra, Wu, Jinzi J., Béliveau, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES CARBON 14 Catechin - analogs & derivatives Catechin - pharmacology Cell Communication Cell Line, Tumor COLLAGEN Collagen Type I - pharmacology Drug Synergism EGCg HORMONES Humans Kinetics Laminin receptor precursor LIGANDS Matrix Metalloproteinase 9 - metabolism METASTASES Metastasis MMP-9 Neoplasm Metastasis - drug therapy NEOPLASMS Oligopeptides - pharmacology Peptide Fragments - metabolism PEPTIDES PRECURSOR PROSTATE Prostate cancer Prostatic Secretory Proteins - metabolism Protein Precursors - metabolism RECEPTORS Receptors, Cell Surface - metabolism Receptors, Laminin - metabolism UPTAKE
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