Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges
The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this n...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2006-09, Vol.353 (2), p.324-332 |
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| creator | Wang, Danher Hevey, Michael Juompan, Laure Y. Trubey, Charles M. Raja, Nicholas U. Deitz, Stephen B. Woraratanadharm, Jan Luo, Min Yu, Hong Swain, Benjamin M. Moore, Kevin M. Dong, John Y. |
| description | The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guinea pigs. Significantly, guinea pigs vaccinated with at least 5 × 10
7 pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV. |
| doi_str_mv | 10.1016/j.virol.2006.05.033 |
| format | Article |
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7 pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2006.05.033</identifier><identifier>PMID: 16820184</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; Adenoviridae - genetics ; Adenoviridae - metabolism ; ADENOVIRUS ; Amino Acid Sequence ; Animals ; ANTIBODIES ; Antibodies, Viral - blood ; Antigens, Viral - biosynthesis ; Antigens, Viral - genetics ; cAdVax ; Cell Line ; Cercopithecus aethiops ; Challenge ; Ci67 ; Dose-Response Relationship, Immunologic ; Ebola Vaccines - administration & dosage ; Ebola Vaccines - genetics ; Ebola virus ; FEVER ; Filovirus ; Genetic Therapy - methods ; Genetic Vectors - metabolism ; Glycoprotein ; GLYCOPROTEINS ; GUINEA PIGS ; Humans ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Marburg virus ; Marburg Virus Disease - blood ; Marburg Virus Disease - immunology ; Marburg Virus Disease - prevention & control ; Marburgvirus - immunology ; MICE ; Molecular Sequence Data ; MORTALITY ; Musoke ; Ravn ; Recombinant Proteins - biosynthesis ; Recombinant Proteins - genetics ; Sequence Alignment ; Vaccination ; Vaccine ; VACCINES ; Vaccines, Synthetic - administration & dosage ; VIRAL DISEASES ; Viral Envelope Proteins - biosynthesis ; Viral Envelope Proteins - genetics ; Viral Fusion Proteins - biosynthesis ; Viral Fusion Proteins - genetics</subject><ispartof>Virology (New York, N.Y.), 2006-09, Vol.353 (2), p.324-332</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-611a0ae0ef614f276dc863c753d104333aba3c5d993d79f7508d9a19aca13bd3</citedby><cites>FETCH-LOGICAL-c461t-611a0ae0ef614f276dc863c753d104333aba3c5d993d79f7508d9a19aca13bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682206003631$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16820184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/20850564$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Danher</creatorcontrib><creatorcontrib>Hevey, Michael</creatorcontrib><creatorcontrib>Juompan, Laure Y.</creatorcontrib><creatorcontrib>Trubey, Charles M.</creatorcontrib><creatorcontrib>Raja, Nicholas U.</creatorcontrib><creatorcontrib>Deitz, Stephen B.</creatorcontrib><creatorcontrib>Woraratanadharm, Jan</creatorcontrib><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Yu, Hong</creatorcontrib><creatorcontrib>Swain, Benjamin M.</creatorcontrib><creatorcontrib>Moore, Kevin M.</creatorcontrib><creatorcontrib>Dong, John Y.</creatorcontrib><title>Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guinea pigs. Significantly, guinea pigs vaccinated with at least 5 × 10
7 pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Adenoviridae - genetics</subject><subject>Adenoviridae - metabolism</subject><subject>ADENOVIRUS</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>ANTIBODIES</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens, Viral - biosynthesis</subject><subject>Antigens, Viral - genetics</subject><subject>cAdVax</subject><subject>Cell Line</subject><subject>Cercopithecus aethiops</subject><subject>Challenge</subject><subject>Ci67</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Ebola Vaccines - administration & dosage</subject><subject>Ebola Vaccines - genetics</subject><subject>Ebola virus</subject><subject>FEVER</subject><subject>Filovirus</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors - metabolism</subject><subject>Glycoprotein</subject><subject>GLYCOPROTEINS</subject><subject>GUINEA PIGS</subject><subject>Humans</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>Marburg virus</subject><subject>Marburg Virus Disease - blood</subject><subject>Marburg Virus Disease - immunology</subject><subject>Marburg Virus Disease - prevention & control</subject><subject>Marburgvirus - immunology</subject><subject>MICE</subject><subject>Molecular Sequence Data</subject><subject>MORTALITY</subject><subject>Musoke</subject><subject>Ravn</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Recombinant Proteins - genetics</subject><subject>Sequence Alignment</subject><subject>Vaccination</subject><subject>Vaccine</subject><subject>VACCINES</subject><subject>Vaccines, Synthetic - administration & dosage</subject><subject>VIRAL DISEASES</subject><subject>Viral Envelope Proteins - biosynthesis</subject><subject>Viral Envelope Proteins - genetics</subject><subject>Viral Fusion Proteins - biosynthesis</subject><subject>Viral Fusion Proteins - genetics</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EYsvCL0BClpC4JczEieMcOKAKWKRFXPZuufYkdZXExU6q5d_jbitxg5M1o2-e581j7C1CiYDy46E8-RjGsgKQJTQlCPGMbRA6WYCo8TnbANRVIVVV3bBXKR0g120LL9kN5iagqjds2IbpONIjN47mkAXXVJzILiGS4ydjrZ-JH2NYci_xYc2l4Uc_JN7HMPFlH4l4WqLxc-Kh5z9M3K1x4E9K3O7NONI8UHrNXvRmTPTm-t6yh69fHrZ3xf3Pb9-3n-8LW0tcColowBBQL7Huq1Y6q6SwbSMcQi2EMDsjbOO6Tri269sGlOsMdsYaFDsnbtn7i2xIi9fJ-rz33oZ5zuvrClQDjawz9eFCZWO_VkqLnnyyNI5mprAmLZVS-UL_B7ETSgJgBsUFtDGkFKnXx-gnE39rBH1OSx_0U1r6nJaGRue08tS7q_y6m8j9nbnGk4FPF4DyyU6e4tkSzZacj2dHLvh_fvAHwQmoJg</recordid><startdate>20060930</startdate><enddate>20060930</enddate><creator>Wang, Danher</creator><creator>Hevey, Michael</creator><creator>Juompan, Laure Y.</creator><creator>Trubey, Charles M.</creator><creator>Raja, Nicholas U.</creator><creator>Deitz, Stephen B.</creator><creator>Woraratanadharm, Jan</creator><creator>Luo, Min</creator><creator>Yu, Hong</creator><creator>Swain, Benjamin M.</creator><creator>Moore, Kevin M.</creator><creator>Dong, John Y.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20060930</creationdate><title>Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges</title><author>Wang, Danher ; Hevey, Michael ; Juompan, Laure Y. ; Trubey, Charles M. ; Raja, Nicholas U. ; Deitz, Stephen B. ; Woraratanadharm, Jan ; Luo, Min ; Yu, Hong ; Swain, Benjamin M. ; Moore, Kevin M. ; Dong, John Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-611a0ae0ef614f276dc863c753d104333aba3c5d993d79f7508d9a19aca13bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>Adenoviridae - genetics</topic><topic>Adenoviridae - metabolism</topic><topic>ADENOVIRUS</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>ANTIBODIES</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens, Viral - biosynthesis</topic><topic>Antigens, Viral - genetics</topic><topic>cAdVax</topic><topic>Cell Line</topic><topic>Cercopithecus aethiops</topic><topic>Challenge</topic><topic>Ci67</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Ebola Vaccines - administration & dosage</topic><topic>Ebola Vaccines - genetics</topic><topic>Ebola virus</topic><topic>FEVER</topic><topic>Filovirus</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors - metabolism</topic><topic>Glycoprotein</topic><topic>GLYCOPROTEINS</topic><topic>GUINEA PIGS</topic><topic>Humans</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>Marburg virus</topic><topic>Marburg Virus Disease - blood</topic><topic>Marburg Virus Disease - immunology</topic><topic>Marburg Virus Disease - prevention & control</topic><topic>Marburgvirus - immunology</topic><topic>MICE</topic><topic>Molecular Sequence Data</topic><topic>MORTALITY</topic><topic>Musoke</topic><topic>Ravn</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Recombinant Proteins - genetics</topic><topic>Sequence Alignment</topic><topic>Vaccination</topic><topic>Vaccine</topic><topic>VACCINES</topic><topic>Vaccines, Synthetic - administration & dosage</topic><topic>VIRAL DISEASES</topic><topic>Viral Envelope Proteins - biosynthesis</topic><topic>Viral Envelope Proteins - genetics</topic><topic>Viral Fusion Proteins - biosynthesis</topic><topic>Viral Fusion Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Danher</creatorcontrib><creatorcontrib>Hevey, Michael</creatorcontrib><creatorcontrib>Juompan, Laure Y.</creatorcontrib><creatorcontrib>Trubey, Charles M.</creatorcontrib><creatorcontrib>Raja, Nicholas U.</creatorcontrib><creatorcontrib>Deitz, Stephen B.</creatorcontrib><creatorcontrib>Woraratanadharm, Jan</creatorcontrib><creatorcontrib>Luo, Min</creatorcontrib><creatorcontrib>Yu, Hong</creatorcontrib><creatorcontrib>Swain, Benjamin M.</creatorcontrib><creatorcontrib>Moore, Kevin M.</creatorcontrib><creatorcontrib>Dong, John Y.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Danher</au><au>Hevey, Michael</au><au>Juompan, Laure Y.</au><au>Trubey, Charles M.</au><au>Raja, Nicholas U.</au><au>Deitz, Stephen B.</au><au>Woraratanadharm, Jan</au><au>Luo, Min</au><au>Yu, Hong</au><au>Swain, Benjamin M.</au><au>Moore, Kevin M.</au><au>Dong, John Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2006-09-30</date><risdate>2006</risdate><volume>353</volume><issue>2</issue><spage>324</spage><epage>332</epage><pages>324-332</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>The Marburg virus (MARV), an African filovirus closely related to the Ebola virus, causes a deadly hemorrhagic fever in humans, with up to 90% mortality. Currently, treatment of disease is only supportive, and no vaccines are available to prevent spread of MARV infections. In order to address this need, we have developed and characterized a novel recombinant vaccine that utilizes a single complex adenovirus-vectored vaccine (cAdVax) to overexpress a MARV glycoprotein (GP) fusion protein derived from the Musoke and Ci67 strains of MARV. Vaccination with the cAdVaxM(fus) vaccine led to efficient production of MARV-specific antibodies in both mice and guinea pigs. Significantly, guinea pigs vaccinated with at least 5 × 10
7 pfu of cAdVaxM(fus) vaccine were 100% protected against lethal challenges by the Musoke, Ci67 and Ravn strains of MARV, making it a vaccine with trivalent protective efficacy. Therefore, the cAdVaxM(fus) vaccine serves as a promising vaccine candidate to prevent and contain multi-strain infections by MARV.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16820184</pmid><doi>10.1016/j.virol.2006.05.033</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES Adenoviridae - genetics Adenoviridae - metabolism ADENOVIRUS Amino Acid Sequence Animals ANTIBODIES Antibodies, Viral - blood Antigens, Viral - biosynthesis Antigens, Viral - genetics cAdVax Cell Line Cercopithecus aethiops Challenge Ci67 Dose-Response Relationship, Immunologic Ebola Vaccines - administration & dosage Ebola Vaccines - genetics Ebola virus FEVER Filovirus Genetic Therapy - methods Genetic Vectors - metabolism Glycoprotein GLYCOPROTEINS GUINEA PIGS Humans Injections, Intraperitoneal Injections, Subcutaneous Marburg virus Marburg Virus Disease - blood Marburg Virus Disease - immunology Marburg Virus Disease - prevention & control Marburgvirus - immunology MICE Molecular Sequence Data MORTALITY Musoke Ravn Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Sequence Alignment Vaccination Vaccine VACCINES Vaccines, Synthetic - administration & dosage VIRAL DISEASES Viral Envelope Proteins - biosynthesis Viral Envelope Proteins - genetics Viral Fusion Proteins - biosynthesis Viral Fusion Proteins - genetics |
| title | Complex adenovirus-vectored vaccine protects guinea pigs from three strains of Marburg virus challenges |
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