Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells

Nordihydroguaiaretic acid (NDGA), a general lipoxygenase (LOX) enzyme inhibitor, induces apoptosis independently of its activity as a LOX inhibitor in murine pro-B lymphocytes (FL.12 cells) by a mechanism that is still not fully understood. Glutathione depletion, oxidative processes and mitochondria...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 2006-08, Vol.214 (3), p.230-236
Hauptverfasser:	Deshpande, Vaidehee S., Kehrer, James P.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acetylcysteine - pharmacology Animals APOPTOSIS Apoptosis - drug effects B-Lymphocytes - drug effects B-Lymphocytes - enzymology B-Lymphocytes - metabolism Biological and medical sciences BIOLOGICAL STRESS Caspase 3 Caspases - metabolism Cell Line Cytochromes c - metabolism DEPOLARIZATION Dithiothreitol - pharmacology Electrophoresis, Polyacrylamide Gel ENZYME INHIBITORS Enzyme Inhibitors - pharmacology GLUTATHIONE Lipoxygenase Inhibitors - pharmacology LYMPHOCYTES MAPK Masoprocol - pharmacology Medical sciences Mice MITOCHONDRIA Mitogen-Activated Protein Kinases - metabolism NDGA Oxidative stress Oxidative Stress - drug effects PHOSPHORYLATION PHOSPHOTRANSFERASES Toxicology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!