Effects of the differentiated keratinocyte phenotype on expression levels of CYP1–4 family genes in human skin cells

Epoxyeicosatrienoic acids produced by mouse CYP2B19 have been implicated in mechanisms regulating epidermal cornification (Ladd, P.A., Du, L., Capdevila, J.H., Mernaugh, R., Keeney, D.S., 2003. Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratin...

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Veröffentlicht in:	Toxicology and applied pharmacology 2006-06, Vol.213 (2), p.135-144
Hauptverfasser:	Du, Liping, Neis, Mark M., Ladd, Patricia A., Lanza, Diane L., Yost, Garold S., Keeney, Diane S.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Biological and medical sciences Cell Culture Techniques CELL CULTURES Cell Differentiation - physiology CYP Cytochrome P-450 Enzyme System - classification Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Eicosanoids Eicosanoids - metabolism EPIDERMIS Epidermis - cytology Epidermis - enzymology Epithelial differentiation Epoxygenase GENES Humans IN VITRO IN VIVO Isoenzymes - classification Isoenzymes - genetics Isoenzymes - metabolism Keratinocyte Keratinocytes - cytology Keratinocytes - enzymology Male Medical sciences MICE Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism PHENOTYPE POLYMERASE CHAIN REACTION RNA, Messenger - analysis Skin Toxicology Up-Regulation
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