Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET
Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [18 F]-f...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2007, Vol.67 (1), p.91-96 |
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| creator | Lin, Lilie L., M.D Mutic, Sasa, B.S Low, Daniel A., Ph.D LaForest, Richard, Ph.D Vicic, Milos, Ph.D Zoberi, Imran, M.D Miller, Tom R., M.D., Ph.D Grigsby, Perry W., M.D |
| description | Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [18 F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% ( p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% ( p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant ( p = 0.02) and the mid/last implants ( p = 0.008). The dose to 2 cm3 and 5 cm3 of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum. |
| doi_str_mv | 10.1016/j.ijrobp.2006.08.017 |
| format | Article |
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Methods and Materials: Eleven patients who underwent an [18 F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% ( p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% ( p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant ( p = 0.02) and the mid/last implants ( p = 0.008). The dose to 2 cm3 and 5 cm3 of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2006.08.017</identifier><identifier>PMID: 17189066</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; BLADDER ; BRACHYTHERAPY ; Brachytherapy - methods ; CARCINOMAS ; cervix ; Feasibility Studies ; Female ; FLUORINE 18 ; Fluorodeoxyglucose F18 ; GLUCOSE ; Hematology, Oncology and Palliative Medicine ; Humans ; Image Processing, Computer-Assisted - methods ; Middle Aged ; OPTIMIZATION ; PATIENTS ; PET ; PLANNING ; POSITRON COMPUTED TOMOGRAPHY ; Positron-Emission Tomography ; Prospective Studies ; RADIATION DOSES ; RADIATION SOURCE IMPLANTS ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; Radiopharmaceuticals ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; RECTUM ; treatment planning ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - radiotherapy</subject><ispartof>International journal of radiation oncology, biology, physics, 2007, Vol.67 (1), p.91-96</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-5c9c1af13922ef3bd7f61f2756951c2b00a9a87c3cd456c39b139574d6e7f6223</citedby><cites>FETCH-LOGICAL-c509t-5c9c1af13922ef3bd7f61f2756951c2b00a9a87c3cd456c39b139574d6e7f6223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2006.08.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3538,4011,27905,27906,27907,45977</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17189066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/20850299$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Lilie L., M.D</creatorcontrib><creatorcontrib>Mutic, Sasa, B.S</creatorcontrib><creatorcontrib>Low, Daniel A., Ph.D</creatorcontrib><creatorcontrib>LaForest, Richard, Ph.D</creatorcontrib><creatorcontrib>Vicic, Milos, Ph.D</creatorcontrib><creatorcontrib>Zoberi, Imran, M.D</creatorcontrib><creatorcontrib>Miller, Tom R., M.D., Ph.D</creatorcontrib><creatorcontrib>Grigsby, Perry W., M.D</creatorcontrib><title>Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [18 F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% ( p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% ( p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant ( p = 0.02) and the mid/last implants ( p = 0.008). The dose to 2 cm3 and 5 cm3 of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.</description><subject>Adult</subject><subject>Aged</subject><subject>BLADDER</subject><subject>BRACHYTHERAPY</subject><subject>Brachytherapy - methods</subject><subject>CARCINOMAS</subject><subject>cervix</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>FLUORINE 18</subject><subject>Fluorodeoxyglucose F18</subject><subject>GLUCOSE</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Middle Aged</subject><subject>OPTIMIZATION</subject><subject>PATIENTS</subject><subject>PET</subject><subject>PLANNING</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Positron-Emission Tomography</subject><subject>Prospective Studies</subject><subject>RADIATION DOSES</subject><subject>RADIATION SOURCE IMPLANTS</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radiopharmaceuticals</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>RECTUM</subject><subject>treatment planning</subject><subject>Uterine Cervical Neoplasms - diagnostic imaging</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGL1DAQx4Mo3nr6DUQKgm-tk6RNmhfhOO9O8UDBE3wLaTp1U7ttL0kX9tub0gXBF58SyG_-mfkNIa8pFBSoeN8XrvdTMxcMQBRQF0DlE7KjtVQ5r6qfT8kOuICcJ_iCvAihBwBKZfmcXFBJawVC7MiXq9bM0R0xa7yx-1PcozfzKYseTTzgGLN5MOPoxl9ZN_nMoj86a4bMmjHdsyWsL7cf7_JvNw8vybPODAFfnc9L8uP25uH6U37_9e7z9dV9bitQMa-sstR0lCvGsONNKztBOyYroSpqWQNglKml5bYtK2G5ahJaybIVmEjG-CV5u-VOITodrIto93YaR7RRM6grYEol6t1GzX56XDBEfXDB4pDGwWkJWtRclqWkCSw30PopBI-dnr07GH_SFPSqWvd6U61X1RpqnVSnsjfn_KU5YPu36Ow2AR82AJOLo0O_topJW-v82mk7uf_98G-AHdy46v-NJwz9tPgxedZUB6ZBf1_XvW4bBDDJueR_ABLfpSI</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Lin, Lilie L., M.D</creator><creator>Mutic, Sasa, B.S</creator><creator>Low, Daniel A., Ph.D</creator><creator>LaForest, Richard, Ph.D</creator><creator>Vicic, Milos, Ph.D</creator><creator>Zoberi, Imran, M.D</creator><creator>Miller, Tom R., M.D., Ph.D</creator><creator>Grigsby, Perry W., M.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>2007</creationdate><title>Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET</title><author>Lin, Lilie L., M.D ; Mutic, Sasa, B.S ; Low, Daniel A., Ph.D ; LaForest, Richard, Ph.D ; Vicic, Milos, Ph.D ; Zoberi, Imran, M.D ; Miller, Tom R., M.D., Ph.D ; Grigsby, Perry W., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-5c9c1af13922ef3bd7f61f2756951c2b00a9a87c3cd456c39b139574d6e7f6223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>BLADDER</topic><topic>BRACHYTHERAPY</topic><topic>Brachytherapy - methods</topic><topic>CARCINOMAS</topic><topic>cervix</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>FLUORINE 18</topic><topic>Fluorodeoxyglucose F18</topic><topic>GLUCOSE</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Middle Aged</topic><topic>OPTIMIZATION</topic><topic>PATIENTS</topic><topic>PET</topic><topic>PLANNING</topic><topic>POSITRON COMPUTED TOMOGRAPHY</topic><topic>Positron-Emission Tomography</topic><topic>Prospective Studies</topic><topic>RADIATION DOSES</topic><topic>RADIATION SOURCE IMPLANTS</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radiopharmaceuticals</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>RECTUM</topic><topic>treatment planning</topic><topic>Uterine Cervical Neoplasms - diagnostic imaging</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Lilie L., M.D</creatorcontrib><creatorcontrib>Mutic, Sasa, B.S</creatorcontrib><creatorcontrib>Low, Daniel A., Ph.D</creatorcontrib><creatorcontrib>LaForest, Richard, Ph.D</creatorcontrib><creatorcontrib>Vicic, Milos, Ph.D</creatorcontrib><creatorcontrib>Zoberi, Imran, M.D</creatorcontrib><creatorcontrib>Miller, Tom R., M.D., Ph.D</creatorcontrib><creatorcontrib>Grigsby, Perry W., M.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Lilie L., M.D</au><au>Mutic, Sasa, B.S</au><au>Low, Daniel A., Ph.D</au><au>LaForest, Richard, Ph.D</au><au>Vicic, Milos, Ph.D</au><au>Zoberi, Imran, M.D</au><au>Miller, Tom R., M.D., Ph.D</au><au>Grigsby, Perry W., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2007</date><risdate>2007</risdate><volume>67</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose: A dosimetric study was conducted to compare intracavitary brachytherapy using both a conventional and a custom loading intended to cover a positron emission tomography (PET)-defined tumor volume in patients with cervix cancer. Methods and Materials: Eleven patients who underwent an [18 F]-fluoro-deoxy-D-glucose (FDG)-PET in conjunction with their first, middle, or last brachytherapy treatment were included in this prospective study. A standard plan that delivers 6.5 Gy to point A under ideal conditions was compared with an optimized plan designed to conform the 6.5-Gy isodose surface to the PET defined volume. Results: A total of 31 intracavitary brachytherapy treatments in conjunction with an FDG-PET were performed. The percent coverage of the target isodose surface for the first implant with and without optimization was 73% and 68% ( p = 0.21). The percent coverage of the target isodose surface for the mid/final implant was 83% and 70% ( p = 0.02), respectively. The dose to point A was higher with the optimized plans for both the first implant ( p = 0.02) and the mid/last implants ( p = 0.008). The dose to 2 cm3 and 5 cm3 of both the bladder and rectum were not significantly different. Conclusions: FDG-PET based treatment planning allowed for improved dose coverage of the tumor without significantly increasing the dose to the bladder and rectum.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17189066</pmid><doi>10.1016/j.ijrobp.2006.08.017</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged BLADDER BRACHYTHERAPY Brachytherapy - methods CARCINOMAS cervix Feasibility Studies Female FLUORINE 18 Fluorodeoxyglucose F18 GLUCOSE Hematology, Oncology and Palliative Medicine Humans Image Processing, Computer-Assisted - methods Middle Aged OPTIMIZATION PATIENTS PET PLANNING POSITRON COMPUTED TOMOGRAPHY Positron-Emission Tomography Prospective Studies RADIATION DOSES RADIATION SOURCE IMPLANTS Radiology RADIOLOGY AND NUCLEAR MEDICINE Radiopharmaceuticals Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods RECTUM treatment planning Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - radiotherapy |
| title | Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET |
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