Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells

Carbon monoxide (CO) and nitric oxide (NO) are two gas molecules which have cytoprotective functions against oxidative stress and inflammatory responses in many cell types. Currently, it is known that NO produced by nitric oxide synthase (NOS) induces heme oxygenase 1 (HO1) expression and CO produce...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-05, Vol.343 (3), p.965-972
Hauptverfasser:	Lee, Bok-Soo, Heo, JungHee, Kim, Yong-Man, Shim, Sang Moo, Pae, Hyun-Ock, Kim, Young-Myeong, Chung, Hun-Taeg
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Active Transport, Cell Nucleus Animals Anti-oxidant response element BIOLOGICAL STRESS CARBON MONOXIDE Carbon Monoxide - pharmacology Carcinoma, Hepatocellular Cell Line, Tumor Cell Nucleus - metabolism Gene Expression Regulation, Enzymologic HEME Heme oxygenase 1 Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - metabolism HEPATOMAS Humans INFLAMMATION LIVER CELLS Liver Neoplasms MAP Kinase Signaling System Mitogen-activated protein kinases NF-E2-related factor NF-E2-Related Factor 2 - metabolism NITRIC OXIDE Nitric oxide/inducible NO synthase OXIDIZERS PHOSPHOTRANSFERASES Promoter Regions, Genetic Rats Response Elements TIME DEPENDENCE Transcriptional Activation TRANSLOCATION Tricarbonyl dichlororuthenium (II) dimmer (RuCO) Up-Regulation
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