Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies
Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyo...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 2006-05, Vol.343 (2), p.555-563 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 563 |
|---|---|
| container_issue | 2 |
| container_start_page | 555 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 343 |
| creator | Stary, Martina Schneider, Mikael Sheikh, Søren P. Weitzer, Georg |
| description | Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis [M. Stary, W. Pasteiner, A. Summer, A. Hrdina, A. Eger, G. Weitzer, Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro, Exp. Cell Res. 310 (2005) 331–341]. Here we report a similar and new function for S100A4, a calcium-binding protein of the EF-hand type. S100A4 is secreted by parietal endoderm and promotes early differentiation and proliferation of cardiomyocytes. Oligomeric S100A4 supports cardiomyogenesis in a concentration-dependent manner, whereas inhibition of autocrine S100A4 severely attenuates cardiomyogenesis. S100A4 specifically influences transcription in differentiating cardiomyocytes, as evident from increased expression of cardiac transcription factor genes
nkx2.5 and
mef2C. These data suggest that S100A4, like SPARC, plays a supportive role in early in vitro cardiomyogenesis. |
| doi_str_mv | 10.1016/j.bbrc.2006.02.161 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_20798936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X06004712</els_id><sourcerecordid>17185805</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-c65cbda978aa9ee752c7b4e21bc74d573187d41d543a1f91ed19360eb90c2533</originalsourceid><addsrcrecordid>eNqFkU1r3DAQhkVoSbZp_0APxVDIze6MrA8LegmhaQqBFrqH3oQszbZabCuVvIX997XZhd6a0xzmmRfeeRh7i9AgoPqwb_o--4YDqAZ4gwov2AbBQM0RxAu2gWVTc4M_rtirUvYAiEKZS3aFSkoBLWzY9pvLkWY3VDSFFCiPVSGfaaZQfUeAW1E95TSmmUpFLg_HyrscYhqP6SdNVGKp4lTR2OdjiqHqU4hUXrOXOzcUenOe12x7_2l791A_fv385e72sfYC27n2Svo-OKM75wyRltzrXhDH3msRpG6x00FgkKJ1uDNIAU2rgHoDnsu2vWbvT7GpzNEWH2fyv3yaJvKz5aBNt-ALdXOilh6_D1RmO8biaRjcROlQrNK6Uy20z4KosZMdyAXkJ9DnVEqmnX3KcXT5aBHsasbu7WrGrmYscLuYWY7endMP_Ujh38lZxQJ8PAG0fOxPpLw2oslTiHktFFL8X_5fenaeWg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17185805</pqid></control><display><type>article</type><title>Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Stary, Martina ; Schneider, Mikael ; Sheikh, Søren P. ; Weitzer, Georg</creator><creatorcontrib>Stary, Martina ; Schneider, Mikael ; Sheikh, Søren P. ; Weitzer, Georg</creatorcontrib><description>Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis [M. Stary, W. Pasteiner, A. Summer, A. Hrdina, A. Eger, G. Weitzer, Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro, Exp. Cell Res. 310 (2005) 331–341]. Here we report a similar and new function for S100A4, a calcium-binding protein of the EF-hand type. S100A4 is secreted by parietal endoderm and promotes early differentiation and proliferation of cardiomyocytes. Oligomeric S100A4 supports cardiomyogenesis in a concentration-dependent manner, whereas inhibition of autocrine S100A4 severely attenuates cardiomyogenesis. S100A4 specifically influences transcription in differentiating cardiomyocytes, as evident from increased expression of cardiac transcription factor genes
nkx2.5 and
mef2C. These data suggest that S100A4, like SPARC, plays a supportive role in early in vitro cardiomyogenesis.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2006.02.161</identifier><identifier>PMID: 16554030</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>60 APPLIED LIFE SCIENCES ; CALCIUM ; Cardiomyocytes ; Cardiomyogenesis ; Cell Differentiation - drug effects ; Cell Line ; CELL PROLIFERATION ; Dose-Response Relationship, Drug ; Embryo, Mammalian - cytology ; Embryo, Mammalian - drug effects ; Embryo, Mammalian - physiology ; Embryoid bodies ; Embryonic stem cells ; Endoderm - secretion ; GENES ; GROWTH FACTORS ; Homeobox Protein Nkx-2.5 ; Homeodomain Proteins - metabolism ; Humans ; IN VITRO ; MADS Domain Proteins - metabolism ; MEF2 Transcription Factors ; Myocytes, Cardiac - cytology ; Myocytes, Cardiac - drug effects ; Myocytes, Cardiac - physiology ; Myogenic Regulatory Factors - metabolism ; S100 Calcium-Binding Protein A4 ; S100 Proteins - administration & dosage ; S100 Proteins - secretion ; S100A4 ; STEM CELLS ; TRANSCRIPTION ; TRANSCRIPTION FACTORS ; Transcription Factors - metabolism</subject><ispartof>Biochemical and biophysical research communications, 2006-05, Vol.343 (2), p.555-563</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-c65cbda978aa9ee752c7b4e21bc74d573187d41d543a1f91ed19360eb90c2533</citedby><cites>FETCH-LOGICAL-c413t-c65cbda978aa9ee752c7b4e21bc74d573187d41d543a1f91ed19360eb90c2533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X06004712$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16554030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/20798936$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Stary, Martina</creatorcontrib><creatorcontrib>Schneider, Mikael</creatorcontrib><creatorcontrib>Sheikh, Søren P.</creatorcontrib><creatorcontrib>Weitzer, Georg</creatorcontrib><title>Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis [M. Stary, W. Pasteiner, A. Summer, A. Hrdina, A. Eger, G. Weitzer, Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro, Exp. Cell Res. 310 (2005) 331–341]. Here we report a similar and new function for S100A4, a calcium-binding protein of the EF-hand type. S100A4 is secreted by parietal endoderm and promotes early differentiation and proliferation of cardiomyocytes. Oligomeric S100A4 supports cardiomyogenesis in a concentration-dependent manner, whereas inhibition of autocrine S100A4 severely attenuates cardiomyogenesis. S100A4 specifically influences transcription in differentiating cardiomyocytes, as evident from increased expression of cardiac transcription factor genes
nkx2.5 and
mef2C. These data suggest that S100A4, like SPARC, plays a supportive role in early in vitro cardiomyogenesis.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>CALCIUM</subject><subject>Cardiomyocytes</subject><subject>Cardiomyogenesis</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Line</subject><subject>CELL PROLIFERATION</subject><subject>Dose-Response Relationship, Drug</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryo, Mammalian - drug effects</subject><subject>Embryo, Mammalian - physiology</subject><subject>Embryoid bodies</subject><subject>Embryonic stem cells</subject><subject>Endoderm - secretion</subject><subject>GENES</subject><subject>GROWTH FACTORS</subject><subject>Homeobox Protein Nkx-2.5</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>IN VITRO</subject><subject>MADS Domain Proteins - metabolism</subject><subject>MEF2 Transcription Factors</subject><subject>Myocytes, Cardiac - cytology</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Myogenic Regulatory Factors - metabolism</subject><subject>S100 Calcium-Binding Protein A4</subject><subject>S100 Proteins - administration & dosage</subject><subject>S100 Proteins - secretion</subject><subject>S100A4</subject><subject>STEM CELLS</subject><subject>TRANSCRIPTION</subject><subject>TRANSCRIPTION FACTORS</subject><subject>Transcription Factors - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVoSbZp_0APxVDIze6MrA8LegmhaQqBFrqH3oQszbZabCuVvIX997XZhd6a0xzmmRfeeRh7i9AgoPqwb_o--4YDqAZ4gwov2AbBQM0RxAu2gWVTc4M_rtirUvYAiEKZS3aFSkoBLWzY9pvLkWY3VDSFFCiPVSGfaaZQfUeAW1E95TSmmUpFLg_HyrscYhqP6SdNVGKp4lTR2OdjiqHqU4hUXrOXOzcUenOe12x7_2l791A_fv385e72sfYC27n2Svo-OKM75wyRltzrXhDH3msRpG6x00FgkKJ1uDNIAU2rgHoDnsu2vWbvT7GpzNEWH2fyv3yaJvKz5aBNt-ALdXOilh6_D1RmO8biaRjcROlQrNK6Uy20z4KosZMdyAXkJ9DnVEqmnX3KcXT5aBHsasbu7WrGrmYscLuYWY7endMP_Ujh38lZxQJ8PAG0fOxPpLw2oslTiHktFFL8X_5fenaeWg</recordid><startdate>20060505</startdate><enddate>20060505</enddate><creator>Stary, Martina</creator><creator>Schneider, Mikael</creator><creator>Sheikh, Søren P.</creator><creator>Weitzer, Georg</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20060505</creationdate><title>Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies</title><author>Stary, Martina ; Schneider, Mikael ; Sheikh, Søren P. ; Weitzer, Georg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-c65cbda978aa9ee752c7b4e21bc74d573187d41d543a1f91ed19360eb90c2533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>CALCIUM</topic><topic>Cardiomyocytes</topic><topic>Cardiomyogenesis</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Line</topic><topic>CELL PROLIFERATION</topic><topic>Dose-Response Relationship, Drug</topic><topic>Embryo, Mammalian - cytology</topic><topic>Embryo, Mammalian - drug effects</topic><topic>Embryo, Mammalian - physiology</topic><topic>Embryoid bodies</topic><topic>Embryonic stem cells</topic><topic>Endoderm - secretion</topic><topic>GENES</topic><topic>GROWTH FACTORS</topic><topic>Homeobox Protein Nkx-2.5</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Humans</topic><topic>IN VITRO</topic><topic>MADS Domain Proteins - metabolism</topic><topic>MEF2 Transcription Factors</topic><topic>Myocytes, Cardiac - cytology</topic><topic>Myocytes, Cardiac - drug effects</topic><topic>Myocytes, Cardiac - physiology</topic><topic>Myogenic Regulatory Factors - metabolism</topic><topic>S100 Calcium-Binding Protein A4</topic><topic>S100 Proteins - administration & dosage</topic><topic>S100 Proteins - secretion</topic><topic>S100A4</topic><topic>STEM CELLS</topic><topic>TRANSCRIPTION</topic><topic>TRANSCRIPTION FACTORS</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stary, Martina</creatorcontrib><creatorcontrib>Schneider, Mikael</creatorcontrib><creatorcontrib>Sheikh, Søren P.</creatorcontrib><creatorcontrib>Weitzer, Georg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stary, Martina</au><au>Schneider, Mikael</au><au>Sheikh, Søren P.</au><au>Weitzer, Georg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2006-05-05</date><risdate>2006</risdate><volume>343</volume><issue>2</issue><spage>555</spage><epage>563</epage><pages>555-563</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis [M. Stary, W. Pasteiner, A. Summer, A. Hrdina, A. Eger, G. Weitzer, Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro, Exp. Cell Res. 310 (2005) 331–341]. Here we report a similar and new function for S100A4, a calcium-binding protein of the EF-hand type. S100A4 is secreted by parietal endoderm and promotes early differentiation and proliferation of cardiomyocytes. Oligomeric S100A4 supports cardiomyogenesis in a concentration-dependent manner, whereas inhibition of autocrine S100A4 severely attenuates cardiomyogenesis. S100A4 specifically influences transcription in differentiating cardiomyocytes, as evident from increased expression of cardiac transcription factor genes
nkx2.5 and
mef2C. These data suggest that S100A4, like SPARC, plays a supportive role in early in vitro cardiomyogenesis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16554030</pmid><doi>10.1016/j.bbrc.2006.02.161</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 2006-05, Vol.343 (2), p.555-563 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_osti_scitechconnect_20798936 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 60 APPLIED LIFE SCIENCES CALCIUM Cardiomyocytes Cardiomyogenesis Cell Differentiation - drug effects Cell Line CELL PROLIFERATION Dose-Response Relationship, Drug Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - physiology Embryoid bodies Embryonic stem cells Endoderm - secretion GENES GROWTH FACTORS Homeobox Protein Nkx-2.5 Homeodomain Proteins - metabolism Humans IN VITRO MADS Domain Proteins - metabolism MEF2 Transcription Factors Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Myogenic Regulatory Factors - metabolism S100 Calcium-Binding Protein A4 S100 Proteins - administration & dosage S100 Proteins - secretion S100A4 STEM CELLS TRANSCRIPTION TRANSCRIPTION FACTORS Transcription Factors - metabolism |
| title | Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T09%3A36%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Parietal%20endoderm%20secreted%20S100A4%20promotes%20early%20cardiomyogenesis%20in%20embryoid%20bodies&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Stary,%20Martina&rft.date=2006-05-05&rft.volume=343&rft.issue=2&rft.spage=555&rft.epage=563&rft.pages=555-563&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2006.02.161&rft_dat=%3Cproquest_osti_%3E17185805%3C/proquest_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17185805&rft_id=info:pmid/16554030&rft_els_id=S0006291X06004712&rfr_iscdi=true |