Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity

Previously, we reported high hepatotoxic sensitivity of type 2 diabetic (DB) rats to three dissimilar hepatotoxicants. Additional work revealed that a normally nonlethal dose of CCl 4 was lethal in DB rats due to inhibited compensatory tissue repair. The present study was conducted to investigate th...

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Veröffentlicht in:	Toxicology and applied pharmacology 2006-03, Vol.211 (3), p.221-232
Hauptverfasser:	Sawant, Sharmilee P., Dnyanmote, Ankur V., Warbritton, Alan, Latendresse, John R., Mehendale, Harihara M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ALANINES Animals Biological and medical sciences BIOLOGICAL REPAIR CARBON 14 CARBON TETRACHLORIDE CCl 4 CELL DIVISION Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance Disease Susceptibility DNA Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance FAILURES Immunohistochemistry INJURIES INSULIN LIVER Liver - drug effects Liver - metabolism Liver - pathology Liver injury Male Medical sciences MORTALITY NECROSIS Proliferating Cell Nuclear Antigen - metabolism RATS Rats, Sprague-Dawley SENSITIVITY Thioacetamide Thioacetamide - toxicity THYMIDINE Tissue repair Toxicology TRITIUM Type 2 diabetes
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