Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice

In utero exposure to valproic acid (VPA) during pregnancy is associated with an increased risk of neural tube defects (NTDs). Although the mechanism by which VPA mediates these effects is unknown, VPA-initiated changes in embryonic protein levels have been implicated. The objectives of this study we...

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Veröffentlicht in:	Toxicology and applied pharmacology 2006-03, Vol.211 (2), p.124-132
Hauptverfasser:	Dawson, Jennifer E., Raymond, Angela M., Winn, Louise M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Anticonvulsants - administration & dosage Anticonvulsants - toxicity bcl-2-Associated X Protein - metabolism Biological and medical sciences BORON CHLORIDES DEFECTS Diseases of the osteoarticular system Diseases of the spine Dose-Response Relationship, Drug EMBRYOS ENZYMES Female Fetal Diseases - chemically induced Fetal Diseases - metabolism Fetal Diseases - prevention & control FOLIC ACID Folic Acid - pharmacology Folic Acid - therapeutic use Gestational Age Immunoblotting Injections, Subcutaneous LEUKEMIA LEUKEMIA VIRUSES LYMPHOMAS Male Medical sciences MICE Murine leukemia virus Neural tube defects Neural Tube Defects - chemically induced Neural Tube Defects - metabolism Neural Tube Defects - prevention & control NF-kappa B - metabolism PANTOTHENIC ACID Pantothenic Acid - pharmacology Pantothenic Acid - therapeutic use PREGNANCY Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-myb - metabolism Proto-Oncogene Proteins c-pim-1 - metabolism PYRAZOLINES Toxicology Tumor Suppressor Protein p53 - metabolism Valproic acid Valproic Acid - administration & dosage Valproic Acid - toxicity Vitamin B Complex - pharmacology
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