1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea

1,2-Naphthoquinone (1,2-NQ) has recently been identified as an environmental quinone in diesel exhaust particles (DEP) and atmospheric PM 2.5. We have found that this quinone is capable of causing a concentration-dependent contraction of tracheal smooth muscle in guinea pigs with EC 50 value of 18.7...

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Veröffentlicht in:	Toxicology and applied pharmacology 2006-01, Vol.210 (1), p.47-54
Hauptverfasser:	Kikuno, Shota, Taguchi, Keiko, Iwamoto, Noriko, Yamano, Shigeru, Cho, Arthur K., Froines, John R., Kumagai, Yoshito
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Naphthoquinone 60 APPLIED LIFE SCIENCES Air Pollutants - toxicity Animals BENZOQUINONES Biological and medical sciences BRADYKININ CALCIUM Calcium Channels, L-Type - metabolism Diesel exhaust particles Dose-Response Relationship, Drug ELECTROPHORESIS GELS GLUTATHIONE GROWTH FACTORS GUINEA PIGS In Vitro Techniques LEAD SULFIDES Lipoxygenase - metabolism Male MASS SPECTROSCOPY Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - enzymology Muscle, Smooth - metabolism MUSCLES Naphthoquinones - toxicity NUCLEAR MAGNETIC RESONANCE OXYGEN PHOSPHATES Phospholipases A - metabolism Phospholipases A2 PHOSPHORYLATION PHOSPHOTRANSFERASES Protein-Tyrosine Kinases - metabolism RECEPTORS Signal transduction Signal Transduction - drug effects Toxicology TRACHEA Trachea - drug effects Trachea - enzymology Trachea - metabolism Tracheal contraction TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - metabolism TYROSINE Vanilloid (capsaicin) receptor 1
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