PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies

Promyelocytic leukemia nuclear bodies (PML-NBs) are implicated in transcriptional regulation. Here we identify a novel transcriptional repressor, PML-associated repressor of transcription (PAROT), which is regulated in its repressor activity through recruitment to PML-NBs. PAROT is a Krüppel-associa...

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Veröffentlicht in:	Experimental cell research 2006-04, Vol.312 (6), p.901-912
Hauptverfasser:	Fleischer, Sandra, Wiemann, Stefan, Will, Hans, Hofmann, Thomas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETYLENE Amino Acid Sequence Cell Line Cell Nucleus - metabolism Cells, Cultured Cloning, Molecular DNA Gene Expression Profiling - methods GENE REGULATION HETEROCHROMATIN Humans KRAB zinc-finger repressor Kruppel-Like Transcription Factors LEUKEMIA Molecular Sequence Data Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism PAROT PML Promyelocytic Leukemia Protein PROTEINS Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism TIF-1β/KAP1 TRANSCRIPTION Transcription Factors - genetics Transcription Factors - metabolism Transcriptional repression Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism ZINC
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