Single nucleotide polymorphism in transcriptional regulatory regions and expression of environmentally responsive genes

Single nucleotide polymorphisms (SNPs) in the human genome are DNA sequence variations that can alter an individual's response to environmental exposure. SNPs in gene coding regions can lead to changes in the biological properties of the encoded protein. In contrast, SNPs in non-coding gene reg...

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Veröffentlicht in:	Toxicology and applied pharmacology 2005-09, Vol.207 (2), p.84-90
Hauptverfasser:	Wang, Xuting, Tomso, Daniel J., Liu, Xuemei, Bell, Douglas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES COMPUTER CODES Databases, Genetic DNA SEQUENCING ENVIRONMENTAL EXPOSURE Environmentally responsive gene FUNCTIONAL ANALYSIS GENE REGULATION GENES Genetic Predisposition to Disease Genetic Variation Genome, Human GENOTYPE Humans NUCLEOTIDES Polymorphism, Single Nucleotide Regulatory element Regulatory Sequences, Nucleic Acid REVIEWS Single nucleotide polymorphism Transcription factor TRANSCRIPTION FACTORS Transcription, Genetic VARIATIONS
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