Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants

The intracellular targeting determinants of oxysterol binding protein (OSBP)-related protein 3 (ORP3) were studied using a series of truncated and point mutated constructs. The pleckstrin homology (PH) domain of ORP3 binds the phosphoinositide-3-kinase (PI3K) products, PI(3,4)P 2 and PI(3,4,5)P 3. A...

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Veröffentlicht in:	Experimental cell research 2005-11, Vol.310 (2), p.445-462
Hauptverfasser:	Lehto, Markku, Hynynen, Riikka, Karjalainen, Katja, Kuismanen, Esa, Hyvärinen, Kati, Olkkonen, Vesa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Amino Acid Motifs Carrier Proteins - analysis Carrier Proteins - genetics Carrier Proteins - metabolism Cell Membrane - chemistry Cell Membrane - metabolism Cells, Cultured ELECTRON MICROSCOPY ENDOPLASMIC RETICULUM Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - metabolism Humans LIGANDS Lipid Metabolism LIPIDS MEMBRANE PROTEINS Membrane Proteins - genetics Membrane Proteins - metabolism PH VALUE PHENYLALANINE Phosphatidylinositols - metabolism Point Mutation Protein Interaction Mapping Protein Structure, Tertiary Sequence Deletion Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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