Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles

Mechanical stimulation has been implicated as an important regulatory factor in tendon homeostasis. In this study, a custom-designed tensile loading system was used to apply controlled mechanical stimulation to isolated tendon fascicles, in order to examine the effects of 5% cyclic tensile strain at...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-10, Vol.336 (2), p.424-429
Hauptverfasser:	Screen, Hazel R.C., Shelton, Julia C., Bader, Dan L., Lee, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adaptation, Physiological - physiology Animals BIOSYNTHESIS CELL PROLIFERATION Cell Survival COLLAGEN Collagen - metabolism Elasticity Extracellular Matrix - physiology HOMEOSTASIS Male Matrix Mechanotransduction Mechanotransduction, Cellular - physiology METABOLISM Periodicity Physical Stimulation - methods Proteoglycans - metabolism Proteomics Rats Rats, Wistar STIMULATION STIMULI Strain Stress, Mechanical Synthesis Tendon TENDONS Tendons - physiology Tenocyte Tensile Strength - physiology Tissue Engineering - methods Up-Regulation - physiology
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