Superoxide targets calcineurin signaling in vascular endothelium

Superoxide emerges as key regulatory molecule in many aspects of vascular physiology and disease, but identification of superoxide targets in the vasculature remains elusive. In this work, we investigated the possibility of inhibition of protein phosphatase calcineurin by superoxide in endothelial c...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-09, Vol.334 (4), p.1061-1067
Hauptverfasser:	Namgaladze, Dmitry, Shcherbyna, Ivanna, Kienhöfer, Joachim, Hofer, H. Werner, Ullrich, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Calcineurin Calcineurin - metabolism CALMODULIN Cattle Cells, Cultured COPPER Dose-Response Relationship, Drug Endothelial Cells - drug effects Endothelial Cells - metabolism ENDOTHELIUM GENE REGULATION Humans INHIBITION Naphthoquinones - administration & dosage NFAT Oxidative stress PHYSIOLOGY Protein phosphatase Redox regulation SENSITIVITY Signal Transduction - drug effects Signal Transduction - physiology Superoxide SUPEROXIDE DISMUTASE Superoxide Dismutase - metabolism Superoxides - metabolism TIRON TRANSCRIPTION FACTORS TRANSLOCATION Vascular disease VASCULAR DISEASES ZINC
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