Long-term androgen deprivation increases Grade 2 and higher late morbidity in prostate cancer patients treated with three-dimensional conformal radiation therapy

Purpose: To determine whether the use of androgen deprivation (AD) increases late morbidity when combined with high-dose three-dimensional conformal radiation therapy (3D-CRT). Methods and materials: Between May 1989 and November 1998, 1,204 patients were treated for prostate cancer with 3D-CRT to a...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2005-06, Vol.62 (2), p.397-405
Hauptverfasser:	Feigenberg, Steven J., Hanlon, Alexandra L., Horwitz, Eric M., Uzzo, Robert G., Eisenberg, Debra, Pollack, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	3D-CRT Aged Aged, 80 and over Androgen Antagonists - adverse effects Androgen Antagonists - therapeutic use ANDROGENS ANTIGENS CARCINOMAS Combined Modality Therapy DIABETES MELLITUS DISEASE INCIDENCE Gastrointestinal Hemorrhage - etiology Gastrointestinal Tract - drug effects Gastrointestinal Tract - radiation effects Gastrointestinal/genitourinary morbidity HEALTH HAZARDS Hormones Humans Male Middle Aged Morbidity MULTIVARIATE ANALYSIS PATIENTS PROSTATE Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - radiotherapy RADIATION DOSES Radiation Injuries - etiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy, Conformal - adverse effects Radiotherapy, Conformal - methods Rectum Regression Analysis Time Factors Urogenital System - drug effects Urogenital System - radiation effects
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