The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity

Cell surface heparan sulfate proteoglycans (HSPGs) mediate internalization of HIV-1 Tat. Herein, we report that human WiDr cells, which express perlecan but no other HSPGs, can internalize 125I-labeled Tat with minimal lysosomal degradation. Pre-treatment of cells with heparitinase almost completely...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2004-12, Vol.330 (2), p.481-486
Hauptverfasser:	Argyris, Elias G., Kulkosky, Joseph, Meyer, Marie E., Xu, Yan, Mukhtar, Muhammad, Pomerantz, Roger J., Williams, Kevin Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AIDS VIRUS ANIMAL CELLS Cell Line Gene Products, tat - metabolism Genes, Reporter Heparan sulfate proteoglycans Heparan Sulfate Proteoglycans - metabolism HIV Long Terminal Repeat HIV-1 - physiology Human immunodeficiency virus 1 Human immunodeficiency virus type I Humans IODINE 125 LABELLED COMPOUNDS Long terminal repeat Polysaccharide-Lyases - metabolism Promoter Regions, Genetic PROMOTERS Protein Transport SULFATES Tat tat Gene Products, Human Immunodeficiency Virus Transcriptional Activation UPTAKE
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