Harnessing Aromatic‐Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification

Peptide engineering efforts have delivered drugs for diverse human diseases. Side chain alteration is among the most common approaches to designing new peptides for specific applications. The peptide backbone can be modified as well, but this strategy has received relatively little attention. Here w...

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Veröffentlicht in:	Angewandte Chemie 2023-10, Vol.135 (40)
Hauptverfasser:	Yu, Zhen, Kreitler, Dale F., Chiu, Yin Ting T., Xu, Ruiwen, Bruchs, Austin T., Bingman, Craig A., Gellman, Samuel H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Drugs Histidine Ligands MATERIALS SCIENCE Osteoporosis Parathyroid hormone Peptides Proteins
Online-Zugang:	Volltext
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