Spectroscopic characterization of Mn2+ and Cd2+ coordination to phosphorothioates in the conserved A9 metal site of the hammerhead ribozyme

Phosphorothioate modifications have widespread use in the field of nucleic acids. As substitution of sulfur for oxygen can alter metal coordination preferences, the phosphorothioate metal-rescue experiment is a powerful method for identifying metal coordination sites that influence specific properti...

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Veröffentlicht in:	Journal of inorganic biochemistry 2022-05, Vol.230 (C), p.111754-111754, Article 111754
Hauptverfasser:	Hunsicker-Wang, Laura M., Vogt, Matthew J., Hoogstraten, Charles G., Cosper, Nathaniel J., Davenport, Audrey M., Hendon, Christopher H., Scott, Robert A., Britt, R. David, DeRose, Victoria J.
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES Biochemistry & Molecular Biology Chemistry Computation DFT EPR ESEEM EXAFS Hammerhead INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Metals Phosphorothioate Ribozyme RNA Spectroscopy
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