Impact of Host Flexibility on Selectivity in a Supramolecular Host-Catalyzed Enantioselective aza-Darzens Reaction

A highly enantioselective aza-Darzens reaction (up to 99% ee) catalyzed by an enantiopure supramolecular host has been discovered. To understand the role of host structure on reaction outcome, nine new gallium­(III)-based enantiopure supramolecular assemblies were prepared via substitution of the ex...

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Veröffentlicht in:Journal of the American Chemical Society 2022-06, Vol.144 (25), p.11425-11433
Hauptverfasser: Bierschenk, Stephen M., Pan, Judy Y., Settineri, Nicholas S., Warzok, Ulrike, Bergman, Robert G., Raymond, Kenneth N., Toste, F. Dean
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Sprache:eng
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