Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics
The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely...
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| Veröffentlicht in: | Nature protocols 2013-12, Vol.8 (12), p.2413-2428 |
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| creator | McCall, Jordan G Kim, Tae-il Shin, Gunchul Huang, Xian Jung, Yei Hwan Al-Hasani, Ream Omenetto, Fiorenzo G Bruchas, Michael R Rogers, John A |
| description | The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. We describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers and their implementation
in vivo
for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin
in vivo
experimentation, can be completed in ∼3–8 weeks. Implementation of these devices allows for chronic (tested for up to 6 months) wireless optogenetic manipulation of neural circuitry in animals navigating complex natural or home-cage environments, interacting socially, and experiencing other freely moving behaviors. |
| doi_str_mv | 10.1038/nprot.2013.158 |
| format | Article |
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in vivo
for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin
in vivo
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in vivo
for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin
in vivo
experimentation, can be completed in ∼3–8 weeks. Implementation of these devices allows for chronic (tested for up to 6 months) wireless optogenetic manipulation of neural circuitry in animals navigating complex natural or home-cage environments, interacting socially, and experiencing other freely moving behaviors.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>631/1647/2198</subject><subject>631/1647/2253</subject><subject>631/1647/334/1874/345</subject><subject>631/61/54/993</subject><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavioural methods</subject><subject>Bioengineering</subject><subject>Biological research</subject><subject>Biological Techniques</subject><subject>Biology, Experimental</subject><subject>Biomedical engineering</subject><subject>Biomedical materials</subject><subject>Brain</subject><subject>Brain research</subject><subject>Circuits</subject><subject>Computational Biology/Bioinformatics</subject><subject>Computer engineering</subject><subject>Devices</subject><subject>Experimentation</subject><subject>Fabrication</subject><subject>Fiber Optic Technology</subject><subject>Fiber optics</subject><subject>Genetics</subject><subject>Implants</subject><subject>Information processing</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Light</subject><subject>Light emitting diodes</subject><subject>Light sources</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microarrays</subject><subject>Mouse</subject><subject>Nerve Net</subject><subject>Nervous system</subject><subject>Neural circuitry</subject><subject>Neural networks</subject><subject>Neurosciences</subject><subject>Optics</subject><subject>Optoelectronic devices</subject><subject>Optogenetics</subject><subject>Optogenetics - 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Academic</collection><collection>OSTI.GOV - Hybrid</collection><collection>OSTI.GOV</collection><jtitle>Nature protocols</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCall, Jordan G</au><au>Kim, Tae-il</au><au>Shin, Gunchul</au><au>Huang, Xian</au><au>Jung, Yei Hwan</au><au>Al-Hasani, Ream</au><au>Omenetto, Fiorenzo G</au><au>Bruchas, Michael R</au><au>Rogers, John A</au><aucorp>Univ. of Illinois at Urbana-Champaign, IL (United States)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics</atitle><jtitle>Nature protocols</jtitle><stitle>Nat Protoc</stitle><addtitle>Nat Protoc</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>8</volume><issue>12</issue><spage>2413</spage><epage>2428</epage><pages>2413-2428</pages><issn>1754-2189</issn><eissn>1750-2799</eissn><abstract>The rise of optogenetics provides unique opportunities to advance materials and biomedical engineering, as well as fundamental understanding in neuroscience. This protocol describes the fabrication of optoelectronic devices for studying intact neural systems. Unlike optogenetic approaches that rely on rigid fiber optics tethered to external light sources, these novel devices carry wirelessly powered microscale, inorganic light-emitting diodes (μ-ILEDs) and multimodal sensors inside the brain. We describe the technical procedures for construction of these devices, their corresponding radiofrequency power scavengers and their implementation
in vivo
for experimental application. In total, the timeline of the procedure, including device fabrication, implantation and preparation to begin
in vivo
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| subjects | 60 APPLIED LIFE SCIENCES 631/1647/2198 631/1647/2253 631/1647/334/1874/345 631/61/54/993 Analytical Chemistry Animals Behavior Behavioural methods Bioengineering Biological research Biological Techniques Biology, Experimental Biomedical engineering Biomedical materials Brain Brain research Circuits Computational Biology/Bioinformatics Computer engineering Devices Experimentation Fabrication Fiber Optic Technology Fiber optics Genetics Implants Information processing Laboratories Life Sciences Light Light emitting diodes Light sources Male Medical research Medicine Mice Mice, Inbred C57BL Microarrays Mouse Nerve Net Nervous system Neural circuitry Neural networks Neurosciences Optics Optoelectronic devices Optogenetics Optogenetics - methods Organic Chemistry Physiological aspects Prostheses and Implants protocol Radio frequency Scavengers Sensors Transplants & implants Wireless Technology |
| title | Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics |
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