Silver salt enabled H/D exchange at the β-position of thiophene rings: synthesis of fully deuterated thiophene derivatives

We disclose a silver catalyzed H/D exchange reaction, which can introduce the deuterium atom at the β position of thiophene rings without the assistance of any coordinating groups. The advantages of this reaction include operation in open air, usage of D O as the deuterium source, good tolerance to...

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Veröffentlicht in:	Organic & biomolecular chemistry 2022-02, Vol.20 (6), p.1176-1180
Hauptverfasser:	Sheng, Fei-Fei, Li, En-Ci, Bai, Jing-Wen, Wang, Cai-Xia, Hu, Guang-Qi, Liu, Kai-Hui, Sun, Zheng-Yi, Shen, Kang, Zhang, Hong-Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Deuteration Deuterium Exchanging Functional groups Hydrogen-deuterium exchange Silver
Online-Zugang:	Volltext
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