VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage

Rare mutations have been proposed to restrict the development of broadly neutralizing antibodies against HIV-1, but this has not been explicitly demonstrated. We hypothesized that such rare mutations might be identified by comparing broadly neutralizing and non-broadly neutralizing branches of an an...

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Veröffentlicht in:	Cell host & microbe 2020-03, Vol.27 (4)
Hauptverfasser:	Shen, Chen-Hsiang, DeKosky, Brandon J., Guo, Yicheng, Xu, Kai, Gu, Ying, Kilam, Divya, Ko, Sung Hee, Kong, Rui, Liu, Kevin, Louder, Mark K., Ou, Li, Zhang, Baoshan, Chao, Cara W., Corcoran, Martin M., Feng, Eric, Huang, Jesse, Normandin, Erica, O’Dell, Sijy, Ransier, Amy, Rawi, Reda, Sastry, Mallika, Schmidt, Stephen D., Wang, Shuishu, Wang, Yiran, Chuang, Gwo-Yu, Doria-Rose, Nicole A., Lin, Bob, Zhou, Tongqing, Boritz, Eli A., Connors, Mark, Douek, Daniel C., Karlsson Hedestam, Gunilla B., Sheng, Zizhang, Shapiro, Lawrence, Mascola, John R., Kwong, Peter D.
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody maturation antibody sequencing B cell ontogeny BASIC BIOLOGICAL SCIENCES broadly neutralizing antibody fusion peptide-directed rare mutations SHM somatic hypermutation
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