Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

SUMOylation is a reversible post-translational modification that regulates protein function through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of SUMOylating proteins involves an enzymatic cascade, the first step of which entails the activation of a SUMO protei...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2021-03, Vol.64 (5), p.2501-2520
Hauptverfasser:	Langston, Steven P, Grossman, Stephen, England, Dylan, Afroze, Roushan, Bence, Neil, Bowman, Douglas, Bump, Nancy, Chau, Ryan, Chuang, Bei-Ching, Claiborne, Christopher, Cohen, Larry, Connolly, Kelly, Duffey, Matthew, Durvasula, Nitya, Freeze, Scott, Gallery, Melissa, Galvin, Katherine, Gaulin, Jeffrey, Gershman, Rachel, Greenspan, Paul, Grieves, Jessica, Guo, Jianping, Gulavita, Nanda, Hailu, Shumet, He, Xingyue, Hoar, Kara, Hu, Yongbo, Hu, Zhigen, Ito, Mitsuhiro, Kim, Mi-Sook, Lane, Scott Weston, Lok, David, Lublinsky, Anya, Mallender, William, McIntyre, Charles, Minissale, James, Mizutani, Hirotake, Mizutani, Miho, Molchinova, Nina, Ono, Koji, Patil, Ashok, Qian, Mark, Riceberg, Jessica, Shindi, Vaishali, Sintchak, Michael D, Song, Keli, Soucy, Teresa, Wang, Yana, Xu, He, Yang, Xiaofeng, Zawadzka, Agatha, Zhang, Ji, Pulukuri, Sai M
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES adducts assays inhibition inhibitors peptides and proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!