Molecular basis for lipid recognition by the prostaglandin D 2 receptor CRTH2

Prostaglandin D (PGD ) signals through the G protein-coupled receptor (GPCR) CRTH2 to mediate various inflammatory responses. CRTH2 is the only member of the prostanoid receptor family that is phylogenetically distant from others, implying a nonconserved mechanism of lipid action on CRTH2. Here, we...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-08, Vol.118 (32)
Hauptverfasser:	Liu, Heng, Deepak, R N V Krishna, Shiriaeva, Anna, Gati, Cornelius, Batyuk, Alexander, Hu, Hao, Weierstall, Uwe, Liu, Wei, Wang, Lei, Cherezov, Vadim, Fan, Hao, Zhang, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	BASIC BIOLOGICAL SCIENCES CRTH2 (DP2) crystal structure Crystallography, X-Ray - methods Humans lipid binding Lipid Metabolism MD simulations Molecular Dynamics Simulation Mutation prostaglandin D2 Prostaglandin D2 - chemistry Prostaglandin D2 - metabolism Protein Conformation Receptors, Immunologic - chemistry Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, Prostaglandin - chemistry Receptors, Prostaglandin - genetics Receptors, Prostaglandin - metabolism
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