Ancient origins of allosteric activation in a Ser-Thr kinase

A myriad of cellular events are regulated by allostery; therefore, evolution of this process is of fundamental interest. Here, we use ancestral sequence reconstruction to resurrect ancestors of two colocalizing proteins, Aurora A kinase and its allosteric activator TPX2 (targeting protein for Xklp2)...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-02, Vol.367 (6480)
Hauptverfasser:	Hadzipasic, Adelajda, Wilson, Christopher, Nguyen, Vy, Kern, Nadja, Kim, Chansik, Pitsawong, Warintra, Villali, Janice, Zheng, Yuejiao, Kern, Dorothee
Format:	Artikel
Sprache:	eng
Schlagworte:	Science & Technology - Other Topics
Online-Zugang:	Volltext
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