Production of 52Mn using a semi-automated module
This work focused on the production and purification of the positron emitter 52Mn (t1/2 = 5.6 d) via the natCr(p,n)52Mn reaction, using a TR24 cyclotron and a semi-automated system for the purification of 52Mn. Based on two-column and three-column systems, the recovery of 52Mn was 79.7 ± 6.2% (n = 3...
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| Veröffentlicht in: | Applied radiation and isotopes 2021-08, Vol.174 (C), p.109741-109741, Article 109741 |
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| container_issue | C |
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| container_title | Applied radiation and isotopes |
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| creator | Pyles, Jennifer M. Massicano, Adriana V.F. Appiah, Jean-Pierre Bartels, Jennifer L. Alford, Aaron Lapi, Suzanne E. |
| description | This work focused on the production and purification of the positron emitter 52Mn (t1/2 = 5.6 d) via the natCr(p,n)52Mn reaction, using a TR24 cyclotron and a semi-automated system for the purification of 52Mn.
Based on two-column and three-column systems, the recovery of 52Mn was 79.7 ± 6.2% (n = 3) and 70.8 ± 3.3% (n = 3), with processing times of 6.9 ± 0.5 h and 8.2 ± 0.6 h, respectively.
•52Mn was produced via irradiation of Cr foils using a solid-target coin system.•A semi-automated module was designed, constructed and optimized for the purification of 52Mn.•ICP-MS was used for elemental analysis of the starting material, after each column and waste for purifications of 52Mn.•HPGe was utilized for the irradiated samples to verify a high purity product with 54Mn contaminants |
| doi_str_mv | 10.1016/j.apradiso.2021.109741 |
| format | Article |
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Based on two-column and three-column systems, the recovery of 52Mn was 79.7 ± 6.2% (n = 3) and 70.8 ± 3.3% (n = 3), with processing times of 6.9 ± 0.5 h and 8.2 ± 0.6 h, respectively.
•52Mn was produced via irradiation of Cr foils using a solid-target coin system.•A semi-automated module was designed, constructed and optimized for the purification of 52Mn.•ICP-MS was used for elemental analysis of the starting material, after each column and waste for purifications of 52Mn.•HPGe was utilized for the irradiated samples to verify a high purity product with 54Mn contaminants <0.25%.</description><identifier>ISSN: 0969-8043</identifier><identifier>EISSN: 1872-9800</identifier><identifier>DOI: 10.1016/j.apradiso.2021.109741</identifier><language>eng</language><publisher>United Kingdom: Elsevier Ltd</publisher><subject>Chemistry ; Chromium ; Cr-52 ; Cyclotron ; Cyclotron target design ; DOTA ; Fluidic system design ; HPGe ; ICP-MS ; Mn-52 ; Positron ; Production purification ; Proton irradiation ; Radioactivity Manganese-52 ; Radiochemistry ; Radiology ; Semi-automated system</subject><ispartof>Applied radiation and isotopes, 2021-08, Vol.174 (C), p.109741-109741, Article 109741</ispartof><rights>2021 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2651-39e33aadbed98fa4175a33bdb7073e70f60377f6b6c9d2f384691b709d424a593</citedby><cites>FETCH-LOGICAL-c2651-39e33aadbed98fa4175a33bdb7073e70f60377f6b6c9d2f384691b709d424a593</cites><orcidid>0000-0001-9049-4275 ; 0000-0002-0137-2397 ; 0000000190494275 ; 0000000201372397</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apradiso.2021.109741$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/1786767$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Pyles, Jennifer M.</creatorcontrib><creatorcontrib>Massicano, Adriana V.F.</creatorcontrib><creatorcontrib>Appiah, Jean-Pierre</creatorcontrib><creatorcontrib>Bartels, Jennifer L.</creatorcontrib><creatorcontrib>Alford, Aaron</creatorcontrib><creatorcontrib>Lapi, Suzanne E.</creatorcontrib><title>Production of 52Mn using a semi-automated module</title><title>Applied radiation and isotopes</title><description>This work focused on the production and purification of the positron emitter 52Mn (t1/2 = 5.6 d) via the natCr(p,n)52Mn reaction, using a TR24 cyclotron and a semi-automated system for the purification of 52Mn.
Based on two-column and three-column systems, the recovery of 52Mn was 79.7 ± 6.2% (n = 3) and 70.8 ± 3.3% (n = 3), with processing times of 6.9 ± 0.5 h and 8.2 ± 0.6 h, respectively.
•52Mn was produced via irradiation of Cr foils using a solid-target coin system.•A semi-automated module was designed, constructed and optimized for the purification of 52Mn.•ICP-MS was used for elemental analysis of the starting material, after each column and waste for purifications of 52Mn.•HPGe was utilized for the irradiated samples to verify a high purity product with 54Mn contaminants <0.25%.</description><subject>Chemistry</subject><subject>Chromium</subject><subject>Cr-52</subject><subject>Cyclotron</subject><subject>Cyclotron target design</subject><subject>DOTA</subject><subject>Fluidic system design</subject><subject>HPGe</subject><subject>ICP-MS</subject><subject>Mn-52</subject><subject>Positron</subject><subject>Production purification</subject><subject>Proton irradiation</subject><subject>Radioactivity Manganese-52</subject><subject>Radiochemistry</subject><subject>Radiology</subject><subject>Semi-automated system</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLxDAUhYMoOI7-BSmu3LTm1aTZKYMvGNGFrkOa3GqGthmTVvDf21Jdu7pw73cO5x6EzgkuCCbialeYfTTOp1BQTMm0VJKTA7QilaS5qjA-RCushMorzNkxOklphzHmlaIrhF9icKMdfOiz0GQlfeqzMfn-PTNZgs7nZhxCZwZwWTeBLZyio8a0Cc5-5xq93d2-bh7y7fP94-Zmm1sqSpIzBYwZ42pwqmoMJ7I0jNWullgykLgRmEnZiFpY5WjDKi4UmY7KccpNqdgaXSy-IQ1eJ-sHsB829D3YQRNZCSnkBF0u0D6GzxHSoDufLLSt6SGMSdOSEq44ZTMqFtTGkFKERu-j70z81gTruUe903896rlHvfQ4Ca8XIUzffnmIcxjoLTgf5ywu-P8sfgDPOXy-</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Pyles, Jennifer M.</creator><creator>Massicano, Adriana V.F.</creator><creator>Appiah, Jean-Pierre</creator><creator>Bartels, Jennifer L.</creator><creator>Alford, Aaron</creator><creator>Lapi, Suzanne E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-9049-4275</orcidid><orcidid>https://orcid.org/0000-0002-0137-2397</orcidid><orcidid>https://orcid.org/0000000190494275</orcidid><orcidid>https://orcid.org/0000000201372397</orcidid></search><sort><creationdate>202108</creationdate><title>Production of 52Mn using a semi-automated module</title><author>Pyles, Jennifer M. ; Massicano, Adriana V.F. ; Appiah, Jean-Pierre ; Bartels, Jennifer L. ; Alford, Aaron ; Lapi, Suzanne E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2651-39e33aadbed98fa4175a33bdb7073e70f60377f6b6c9d2f384691b709d424a593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chemistry</topic><topic>Chromium</topic><topic>Cr-52</topic><topic>Cyclotron</topic><topic>Cyclotron target design</topic><topic>DOTA</topic><topic>Fluidic system design</topic><topic>HPGe</topic><topic>ICP-MS</topic><topic>Mn-52</topic><topic>Positron</topic><topic>Production purification</topic><topic>Proton irradiation</topic><topic>Radioactivity Manganese-52</topic><topic>Radiochemistry</topic><topic>Radiology</topic><topic>Semi-automated system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pyles, Jennifer M.</creatorcontrib><creatorcontrib>Massicano, Adriana V.F.</creatorcontrib><creatorcontrib>Appiah, Jean-Pierre</creatorcontrib><creatorcontrib>Bartels, Jennifer L.</creatorcontrib><creatorcontrib>Alford, Aaron</creatorcontrib><creatorcontrib>Lapi, Suzanne E.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pyles, Jennifer M.</au><au>Massicano, Adriana V.F.</au><au>Appiah, Jean-Pierre</au><au>Bartels, Jennifer L.</au><au>Alford, Aaron</au><au>Lapi, Suzanne E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of 52Mn using a semi-automated module</atitle><jtitle>Applied radiation and isotopes</jtitle><date>2021-08</date><risdate>2021</risdate><volume>174</volume><issue>C</issue><spage>109741</spage><epage>109741</epage><pages>109741-109741</pages><artnum>109741</artnum><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>This work focused on the production and purification of the positron emitter 52Mn (t1/2 = 5.6 d) via the natCr(p,n)52Mn reaction, using a TR24 cyclotron and a semi-automated system for the purification of 52Mn.
Based on two-column and three-column systems, the recovery of 52Mn was 79.7 ± 6.2% (n = 3) and 70.8 ± 3.3% (n = 3), with processing times of 6.9 ± 0.5 h and 8.2 ± 0.6 h, respectively.
•52Mn was produced via irradiation of Cr foils using a solid-target coin system.•A semi-automated module was designed, constructed and optimized for the purification of 52Mn.•ICP-MS was used for elemental analysis of the starting material, after each column and waste for purifications of 52Mn.•HPGe was utilized for the irradiated samples to verify a high purity product with 54Mn contaminants <0.25%.</abstract><cop>United Kingdom</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.apradiso.2021.109741</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-9049-4275</orcidid><orcidid>https://orcid.org/0000-0002-0137-2397</orcidid><orcidid>https://orcid.org/0000000190494275</orcidid><orcidid>https://orcid.org/0000000201372397</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Chemistry Chromium Cr-52 Cyclotron Cyclotron target design DOTA Fluidic system design HPGe ICP-MS Mn-52 Positron Production purification Proton irradiation Radioactivity Manganese-52 Radiochemistry Radiology Semi-automated system |
| title | Production of 52Mn using a semi-automated module |
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