Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition

Proximal tubular epithelial cells (PTEC) in the S1 segment of the kidney abundantly express sodium-glucose co-transporters (SGLT) that play a critical role in whole body glucose homeostasis. We recently reported suppression of RECK (Reversion Inducing Cysteine Rich Protein with Kazal Motifs), a memb...

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Veröffentlicht in:	Cellular signalling 2020-04, Vol.68 (C), p.109506-109506, Article 109506
Hauptverfasser:	Das, Nitin A., Carpenter, Andrea J., Belenchia, Anthony, Aroor, Annayya R., Noda, Makoto, Siebenlist, Ulrich, Chandrasekar, Bysani, DeMarco, Vincent G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Diabetic kidney disease Fibrosis Inflammation SGLT2
Online-Zugang:	Volltext
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