Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate antivirulence agent against hypervirulent Klebsiella pneumoniae

•Rifampicin (RFP) has strong mucoviscosity-suppressing activity against hypervirulent Klebsiella pneumoniae (hvKP).•RFP inhibits capsular polysaccharide biosynthesis, reducing capsular thickness.•RFP exerts its effect through inhibition of rmpA gene transcription.•RFP may serve as a potential antivi...

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Veröffentlicht in:	International journal of antimicrobial agents 2019-08, Vol.54 (2), p.167-175
Hauptverfasser:	Namikawa, Hiroki, Oinuma, Ken-Ichi, Sakiyama, Arata, Tsubouchi, Taishi, Tahara, Yuhei O., Yamada, Koichi, Niki, Mamiko, Takemoto, Yasuhiko, Miyata, Makoto, Kaneko, Yukihiro, Shuto, Taichi, Kakeya, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-mucoviscous Antivirulence Capsular polysaccharide Hypermucoviscous Hypervirulent Klebsiella pneumoniae Rifampicin
Online-Zugang:	Volltext
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