Prediction of paclitaxel pharmacokinetic based on in vitro studies: Interaction with membrane models and human serum albumin

[Display omitted] •PTX spontaneously partitions in fluid disordered and gel ordered membrane phases.•PTX fluidizes membrane and changes lipid packing parameters in the gel ordered phase.•PTX distorts the membrane polar region arrangement and interacts with the alkyl chains.•PTX-HSA binding retains o...

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Veröffentlicht in:	International journal of pharmaceutics 2020-04, Vol.580 (C), p.119222, Article 119222
Hauptverfasser:	Carvalho, Ana M., Fernandes, Eduarda, Gonçalves, Hugo, Giner-Casares, Juan J., Bernstorff, Sigrid, Nieder, Jana B., Real Oliveira, M. Elisabete C.D., Lúcio, Marlene
Format:	Artikel
Sprache:	eng
Schlagworte:	ADMET/PK prediction Atomic force microscopy Cell Membrane - metabolism Drug Carriers - metabolism Drug Development - methods Dynamic light scattering Humans Hydrophobic and Hydrophilic Interactions Membrane model systems Nanoparticles - metabolism Paclitaxel Paclitaxel - pharmacokinetics Partition coefficient Phospholipids - metabolism Serum Albumin, Human - metabolism
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