Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α

Glutamatergic dysregulation has served as one common pathophysiology of major depressive disorder (MDD) and a promising target for treatment intervention. Previous studies implicate neurotransmission via metabotropic glutamate receptors (mGluRs) and Homer1 in stress-induced anhedonia, but the mechan...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2019-12, Vol.95 (C), p.109682-109682, Article 109682
Hauptverfasser:	Li, Ming-Xing, Li, Qian, Sun, Xue-Jiao, Luo, Can, Li, Yong, Wang, Ya-Nan, Chen, Jing, Gong, Chen-Zi, Li, Ya-Jie, Shi, Li-Ping, Zheng, Yi-Feng, Li, Rong-Chun, Huang, Xiao-Lin, Xiong, Qiu-Ju, Chen, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPARs Chronic stress ER stress Homer1 LTD
Online-Zugang:	Volltext
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