Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma
To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images. Prospective, cross-sectional study. Thirty-four patients with primary ope...
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| Veröffentlicht in: | American journal of ophthalmology 2019-12, Vol.208 (C), p.313-322 |
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| creator | Akagi, Tadamichi Uji, Akihito Okamoto, Yoko Suda, Kenji Kameda, Takanori Nakanishi, Hideo Ikeda, Hanako Ohashi Miyake, Masahiro Nakano, Eri Motozawa, Naohiro Tsujikawa, Akitaka |
| description | To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images.
Prospective, cross-sectional study.
Thirty-four patients with primary open-angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain the AS-OCTA images of the corneoscleral limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 to 1000 μm) layers. The vessel density was compared between healthy and glaucoma eyes, and the associations of the vessel density with possible confounding factors were analyzed using univariable and multivariable analyses.
The vessel density was not significantly different between healthy eyes and eyes with glaucoma. There was a significant association of superficial vessel density with the use of a prostaglandin analog (P = .007) and with nasal location (P = .016) in eyes with glaucoma. Deep vessel density was significantly smaller with advancing age (P = .029) in healthy eyes and greater with higher intraocular pressure (P = .021) in eyes with treated glaucoma.
AS-OCTA images may be useful for the objective assessment of conjunctival hyperemia and helpful for understanding the pathophysiology of post-trabecular aqueous humor outflow. |
| doi_str_mv | 10.1016/j.ajo.2019.05.008 |
| format | Article |
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Prospective, cross-sectional study.
Thirty-four patients with primary open-angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain the AS-OCTA images of the corneoscleral limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 to 1000 μm) layers. The vessel density was compared between healthy and glaucoma eyes, and the associations of the vessel density with possible confounding factors were analyzed using univariable and multivariable analyses.
The vessel density was not significantly different between healthy eyes and eyes with glaucoma. There was a significant association of superficial vessel density with the use of a prostaglandin analog (P = .007) and with nasal location (P = .016) in eyes with glaucoma. Deep vessel density was significantly smaller with advancing age (P = .029) in healthy eyes and greater with higher intraocular pressure (P = .021) in eyes with treated glaucoma.
AS-OCTA images may be useful for the objective assessment of conjunctival hyperemia and helpful for understanding the pathophysiology of post-trabecular aqueous humor outflow.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2019.05.008</identifier><identifier>PMID: 31102577</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anterior Eye Segment - diagnostic imaging ; Automation ; Conjunctiva - blood supply ; Conjunctiva - diagnostic imaging ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Glaucoma ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Gonioscopy ; Humans ; Intraocular Pressure - physiology ; Limbus Corneae - blood supply ; Limbus Corneae - diagnostic imaging ; Male ; Medical imaging ; Middle Aged ; Ophthalmology ; Optics ; Photography ; Prospective Studies ; Sclera - blood supply ; Sclera - diagnostic imaging ; Slit Lamp Microscopy ; Surgery ; Tomography ; Tomography, Optical Coherence ; Tonometry, Ocular ; Visual Field Tests ; Visual Fields - physiology</subject><ispartof>American journal of ophthalmology, 2019-12, Vol.208 (C), p.313-322</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><rights>2019. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-dbfa673e569b4206dc38b6ddf19ca00cd59c56ed08cc488651fecc30757b6fc13</citedby><cites>FETCH-LOGICAL-c517t-dbfa673e569b4206dc38b6ddf19ca00cd59c56ed08cc488651fecc30757b6fc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939419302284$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31102577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1702260$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Akagi, Tadamichi</creatorcontrib><creatorcontrib>Uji, Akihito</creatorcontrib><creatorcontrib>Okamoto, Yoko</creatorcontrib><creatorcontrib>Suda, Kenji</creatorcontrib><creatorcontrib>Kameda, Takanori</creatorcontrib><creatorcontrib>Nakanishi, Hideo</creatorcontrib><creatorcontrib>Ikeda, Hanako Ohashi</creatorcontrib><creatorcontrib>Miyake, Masahiro</creatorcontrib><creatorcontrib>Nakano, Eri</creatorcontrib><creatorcontrib>Motozawa, Naohiro</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><title>Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images.
Prospective, cross-sectional study.
Thirty-four patients with primary open-angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain the AS-OCTA images of the corneoscleral limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 to 1000 μm) layers. The vessel density was compared between healthy and glaucoma eyes, and the associations of the vessel density with possible confounding factors were analyzed using univariable and multivariable analyses.
The vessel density was not significantly different between healthy eyes and eyes with glaucoma. There was a significant association of superficial vessel density with the use of a prostaglandin analog (P = .007) and with nasal location (P = .016) in eyes with glaucoma. Deep vessel density was significantly smaller with advancing age (P = .029) in healthy eyes and greater with higher intraocular pressure (P = .021) in eyes with treated glaucoma.
AS-OCTA images may be useful for the objective assessment of conjunctival hyperemia and helpful for understanding the pathophysiology of post-trabecular aqueous humor outflow.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anterior Eye Segment - diagnostic imaging</subject><subject>Automation</subject><subject>Conjunctiva - blood supply</subject><subject>Conjunctiva - diagnostic imaging</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Gonioscopy</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Limbus Corneae - blood supply</subject><subject>Limbus Corneae - diagnostic imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Optics</subject><subject>Photography</subject><subject>Prospective Studies</subject><subject>Sclera - blood supply</subject><subject>Sclera - diagnostic imaging</subject><subject>Slit Lamp Microscopy</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence</subject><subject>Tonometry, Ocular</subject><subject>Visual Field Tests</subject><subject>Visual Fields - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-L1DAYh4so7rj6AbxI0IuX1qR_khZPw6DrwMIKjueQefO2k9ImY5Iu7Cfwa5syux48eEoCz_sL7-_JsreMFowy_mks1OiKkrKuoE1Bafss27BWdDlrO_Y821BKy7yruvoqexXCmJ5c1OJldlUxRstGiE32e2sjeuM8-YHDjDaSu3M0oCaycyf0aAHJwc1u8Op8eiBbO5in-35Wg7EDcX1i7bhYiOZeEWU12dvoVYAJvSLGkoNHFVGT797Myj-kL9DmKWpCcjOpBdysXmcvejUFfPN4Xmc_v3457L7lt3c3-932NoeGiZjrY6-4qLDh3bEuKddQtUeudc86UJSCbjpoOGraAtRtyxvWI0BFRSOOvAdWXWfvL7kuRCMDmIhwAmctQpRM0LLkNEEfL9DZu18LhihnEwCnSVl0S5BlWZW0bkTNE_rhH3R0i7dpBVlWrGM89dwmil0o8C4Ej708X6qQjMpVpRxlUilXlZI2MqlMM-8ek5fjjPrvxJO7BHy-AJj6ujfo13VWYdr4dRvtzH_i_wCdnq-7</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Akagi, Tadamichi</creator><creator>Uji, Akihito</creator><creator>Okamoto, Yoko</creator><creator>Suda, Kenji</creator><creator>Kameda, Takanori</creator><creator>Nakanishi, Hideo</creator><creator>Ikeda, Hanako Ohashi</creator><creator>Miyake, Masahiro</creator><creator>Nakano, Eri</creator><creator>Motozawa, Naohiro</creator><creator>Tsujikawa, Akitaka</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>201912</creationdate><title>Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma</title><author>Akagi, Tadamichi ; Uji, Akihito ; Okamoto, Yoko ; Suda, Kenji ; Kameda, Takanori ; Nakanishi, Hideo ; Ikeda, Hanako Ohashi ; Miyake, Masahiro ; Nakano, Eri ; Motozawa, Naohiro ; Tsujikawa, Akitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-dbfa673e569b4206dc38b6ddf19ca00cd59c56ed08cc488651fecc30757b6fc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anterior Eye Segment - diagnostic imaging</topic><topic>Automation</topic><topic>Conjunctiva - blood supply</topic><topic>Conjunctiva - diagnostic imaging</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Gonioscopy</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Limbus Corneae - blood supply</topic><topic>Limbus Corneae - diagnostic imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Optics</topic><topic>Photography</topic><topic>Prospective Studies</topic><topic>Sclera - blood supply</topic><topic>Sclera - diagnostic imaging</topic><topic>Slit Lamp Microscopy</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence</topic><topic>Tonometry, Ocular</topic><topic>Visual Field Tests</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akagi, Tadamichi</creatorcontrib><creatorcontrib>Uji, Akihito</creatorcontrib><creatorcontrib>Okamoto, Yoko</creatorcontrib><creatorcontrib>Suda, Kenji</creatorcontrib><creatorcontrib>Kameda, Takanori</creatorcontrib><creatorcontrib>Nakanishi, Hideo</creatorcontrib><creatorcontrib>Ikeda, Hanako Ohashi</creatorcontrib><creatorcontrib>Miyake, Masahiro</creatorcontrib><creatorcontrib>Nakano, Eri</creatorcontrib><creatorcontrib>Motozawa, Naohiro</creatorcontrib><creatorcontrib>Tsujikawa, Akitaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akagi, Tadamichi</au><au>Uji, Akihito</au><au>Okamoto, Yoko</au><au>Suda, Kenji</au><au>Kameda, Takanori</au><au>Nakanishi, Hideo</au><au>Ikeda, Hanako Ohashi</au><au>Miyake, Masahiro</au><au>Nakano, Eri</au><au>Motozawa, Naohiro</au><au>Tsujikawa, Akitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>208</volume><issue>C</issue><spage>313</spage><epage>322</epage><pages>313-322</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images.
Prospective, cross-sectional study.
Thirty-four patients with primary open-angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain the AS-OCTA images of the corneoscleral limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 to 1000 μm) layers. The vessel density was compared between healthy and glaucoma eyes, and the associations of the vessel density with possible confounding factors were analyzed using univariable and multivariable analyses.
The vessel density was not significantly different between healthy eyes and eyes with glaucoma. There was a significant association of superficial vessel density with the use of a prostaglandin analog (P = .007) and with nasal location (P = .016) in eyes with glaucoma. Deep vessel density was significantly smaller with advancing age (P = .029) in healthy eyes and greater with higher intraocular pressure (P = .021) in eyes with treated glaucoma.
AS-OCTA images may be useful for the objective assessment of conjunctival hyperemia and helpful for understanding the pathophysiology of post-trabecular aqueous humor outflow.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31102577</pmid><doi>10.1016/j.ajo.2019.05.008</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Anterior Eye Segment - diagnostic imaging Automation Conjunctiva - blood supply Conjunctiva - diagnostic imaging Cross-Sectional Studies Female Fluorescein Angiography Glaucoma Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Gonioscopy Humans Intraocular Pressure - physiology Limbus Corneae - blood supply Limbus Corneae - diagnostic imaging Male Medical imaging Middle Aged Ophthalmology Optics Photography Prospective Studies Sclera - blood supply Sclera - diagnostic imaging Slit Lamp Microscopy Surgery Tomography Tomography, Optical Coherence Tonometry, Ocular Visual Field Tests Visual Fields - physiology |
| title | Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma |
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