Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics
Highlights • Alterations in glycosylation are hallmarks of malignant transformation in the gastric and colorectal tract. • Altered protein glycosylation favors malignant phenotypes and contributes to poor outcome. • Advances in glycomics, glycoproteomics and glycoengineering have broadened our under...
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| Veröffentlicht in: | Cancer letters 2017-02, Vol.387 (C), p.32-45 |
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| container_issue | C |
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| container_title | Cancer letters |
| container_volume | 387 |
| creator | Ferreira, José Alexandre Magalhães, Ana Gomes, Joana Peixoto, Andreia Gaiteiro, Cristiana Fernandes, Elisabete Santos, Lúcio Lara Reis, Celso A |
| description | Highlights • Alterations in glycosylation are hallmarks of malignant transformation in the gastric and colorectal tract. • Altered protein glycosylation favors malignant phenotypes and contributes to poor outcome. • Advances in glycomics, glycoproteomics and glycoengineering have broadened our understanding of the human glycoproteome. • A comprehensive glycomic and glycoproteomic characterization of human tumors will allow true precision medicine setting. • Cancer-associated glycans hold tremendous potential for non-invasive cancer detection and targeted therapeutics. |
| doi_str_mv | 10.1016/j.canlet.2016.01.044 |
| format | Article |
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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2017-02, Vol.387 (C), p.32-45 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antigens Biomarkers Biosynthesis Blood groups Cancer Cancer glycans Cancer therapies Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Gastric cancer Glycoproteins - metabolism Glycoprotomics Glycosylation Hematology, Oncology and Palliative Medicine Humans Medicine Metastasis Neoplasm Proteins - metabolism Polypeptides Polysaccharides - metabolism Protein glycosylation Proteins Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach Neoplasms - therapy Targeted therapeutics Tumors |
| title | Protein glycosylation in gastric and colorectal cancers: Toward cancer detection and targeted therapeutics |
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