Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid

Thyroid homeostasis can be disturbed due to thiocyanate exposure from the diet or tobacco smoke. Thiocyanate inhibits both thyroidal uptake of iodide, via the sodium-iodide symporter (NIS), and thyroid hormone (TH) synthesis in the thyroid, via thyroid peroxidase (TPO), but the mode of action of thi...

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Veröffentlicht in:	Toxicology and applied pharmacology 2016-09, Vol.307 (C), p.19-34
Hauptverfasser:	Willemin, Marie-Emilie, Lumen, Annie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bayesian Humans Male Models, Biological NIS PBPK model Rats Rats, Sprague-Dawley Rats, Wistar Sulfates - metabolism Sulfur - metabolism Thiocyanate Thiocyanates - blood Thiocyanates - pharmacokinetics Thiocyanates - urine Thyroid Thyroid Gland - metabolism TPO
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