Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism

Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism

Metabolites control immune cell functions, and delivery of these metabolites in a sustained manner may be able to modulate function of the immune cells. In this study, alpha-ketoglutarate (aKG) and diol based polymeric-microparticles (termed paKG MPs) were synthesized to provide sustained release of...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-05, Vol.8 (24)
Hauptverfasser: Mangal, Joslyn L., Inamdar, Sahil, Yang, Yi, Dutta, Subhadeep, Wankhede, Mamta, Shi, Xiaojian, Gu, Haiwei, Green, Matthew, Rege, Kaushal, Curtis, Marion, Acharya, Abhinav P.
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container_issue 24
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container_title Journal of materials chemistry. B, Materials for biology and medicine
container_volume 8
creator Mangal, Joslyn L.
Inamdar, Sahil
Yang, Yi
Dutta, Subhadeep
Wankhede, Mamta
Shi, Xiaojian
Gu, Haiwei
Green, Matthew
Rege, Kaushal
Curtis, Marion
Acharya, Abhinav P.
description Metabolites control immune cell functions, and delivery of these metabolites in a sustained manner may be able to modulate function of the immune cells. In this study, alpha-ketoglutarate (aKG) and diol based polymeric-microparticles (termed paKG MPs) were synthesized to provide sustained release of aKG and promote an immunosuppressive cellular phenotype. Notably, after association with dendritic cells (DCs), paKG MPs modulated the intracellular metabolic-profile/pathways, and decreased glycolysis and mitochondrial respiration in vitro. These metabolic changes resulted in modulation of MHC-II, CD86 expression in DCs, and altered the frequency of regulatory T cells (Tregs), and T-helper type-1/2/17 cells in vitro. In conclusion, this unique strategy of intracellular delivery of key-metabolites in a sustained manner provides a new direction in immunometabolism field-based immunotherapy with potential applications in different diseases associated with immune disorders.
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title Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism
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