Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites
The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their...
Gespeichert in:
| Veröffentlicht in: | Ceramics international 2019-05, Vol.45 (7), p.8195-8203 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 8203 |
|---|---|
| container_issue | 7 |
| container_start_page | 8195 |
| container_title | Ceramics international |
| container_volume | 45 |
| creator | Vassal, Mariana F. Nunes-Pereira, J. Miguel, Sónia P. Correia, Ilídio J. Silva, Abílio P. |
| description | The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application. |
| doi_str_mv | 10.1016/j.ceramint.2019.01.122 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_1636463</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0272884219301270</els_id><sourcerecordid>S0272884219301270</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-6860934cfadf2da900f7a0373f454d213917deb3190e8ff66ce70aa83d90a5643</originalsourceid><addsrcrecordid>eNqFkEtPwzAQhC0EEqXwF1DEmYT1o05yA1W8JFAvcOGA5fpBXaVxZLuI_nscCmdOq13Nt6MZhM4xVBgwv1pXygS5cX2qCOC2AlxhQg7QBDc1LWk744doAqQmZdMwcoxOYlxDBlsGE_T-7FTwMYWtStsgu8tiY9RK9k7JrpC9LpbOd_7jZx2CH0xIzsTC22K108F_7eQgk0umKIu5fAsLOgLKbwYf8zWeoiMru2jOfucUvd7dvswfyqfF_eP85qlUDEMqecOhpUxZqS3RsgWwtQRaU8tmTBNMW1xrs6S4BdNYy7kyNUjZUN2CnHFGp-hi_zdHcSKq7K1Wyve9UUlgTjnjNIv4XjQmjsFYMQS3kWEnMIixSrEWf1WKsUoBWOQqM3i9B02O8OlMGB1Mr4x2YTTQ3v334huz6YG1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites</title><source>Elsevier ScienceDirect Journals</source><creator>Vassal, Mariana F. ; Nunes-Pereira, J. ; Miguel, Sónia P. ; Correia, Ilídio J. ; Silva, Abílio P.</creator><creatorcontrib>Vassal, Mariana F. ; Nunes-Pereira, J. ; Miguel, Sónia P. ; Correia, Ilídio J. ; Silva, Abílio P.</creatorcontrib><description>The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.</description><identifier>ISSN: 0272-8842</identifier><identifier>EISSN: 1873-3956</identifier><identifier>DOI: 10.1016/j.ceramint.2019.01.122</identifier><language>eng</language><publisher>Italy: Elsevier Ltd</publisher><subject>Bioactivity ; Calcium zirconate ; Ceramic biocomposites ; Hydroxyapatite ; Mechanical properties</subject><ispartof>Ceramics international, 2019-05, Vol.45 (7), p.8195-8203</ispartof><rights>2019 Elsevier Ltd and Techna Group S.r.l.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-6860934cfadf2da900f7a0373f454d213917deb3190e8ff66ce70aa83d90a5643</citedby><cites>FETCH-LOGICAL-c410t-6860934cfadf2da900f7a0373f454d213917deb3190e8ff66ce70aa83d90a5643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272884219301270$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/1636463$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Vassal, Mariana F.</creatorcontrib><creatorcontrib>Nunes-Pereira, J.</creatorcontrib><creatorcontrib>Miguel, Sónia P.</creatorcontrib><creatorcontrib>Correia, Ilídio J.</creatorcontrib><creatorcontrib>Silva, Abílio P.</creatorcontrib><title>Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites</title><title>Ceramics international</title><description>The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.</description><subject>Bioactivity</subject><subject>Calcium zirconate</subject><subject>Ceramic biocomposites</subject><subject>Hydroxyapatite</subject><subject>Mechanical properties</subject><issn>0272-8842</issn><issn>1873-3956</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkEtPwzAQhC0EEqXwF1DEmYT1o05yA1W8JFAvcOGA5fpBXaVxZLuI_nscCmdOq13Nt6MZhM4xVBgwv1pXygS5cX2qCOC2AlxhQg7QBDc1LWk744doAqQmZdMwcoxOYlxDBlsGE_T-7FTwMYWtStsgu8tiY9RK9k7JrpC9LpbOd_7jZx2CH0xIzsTC22K108F_7eQgk0umKIu5fAsLOgLKbwYf8zWeoiMru2jOfucUvd7dvswfyqfF_eP85qlUDEMqecOhpUxZqS3RsgWwtQRaU8tmTBNMW1xrs6S4BdNYy7kyNUjZUN2CnHFGp-hi_zdHcSKq7K1Wyve9UUlgTjnjNIv4XjQmjsFYMQS3kWEnMIixSrEWf1WKsUoBWOQqM3i9B02O8OlMGB1Mr4x2YTTQ3v334huz6YG1</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Vassal, Mariana F.</creator><creator>Nunes-Pereira, J.</creator><creator>Miguel, Sónia P.</creator><creator>Correia, Ilídio J.</creator><creator>Silva, Abílio P.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>OTOTI</scope></search><sort><creationdate>20190501</creationdate><title>Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites</title><author>Vassal, Mariana F. ; Nunes-Pereira, J. ; Miguel, Sónia P. ; Correia, Ilídio J. ; Silva, Abílio P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-6860934cfadf2da900f7a0373f454d213917deb3190e8ff66ce70aa83d90a5643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bioactivity</topic><topic>Calcium zirconate</topic><topic>Ceramic biocomposites</topic><topic>Hydroxyapatite</topic><topic>Mechanical properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vassal, Mariana F.</creatorcontrib><creatorcontrib>Nunes-Pereira, J.</creatorcontrib><creatorcontrib>Miguel, Sónia P.</creatorcontrib><creatorcontrib>Correia, Ilídio J.</creatorcontrib><creatorcontrib>Silva, Abílio P.</creatorcontrib><collection>CrossRef</collection><collection>OSTI.GOV</collection><jtitle>Ceramics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vassal, Mariana F.</au><au>Nunes-Pereira, J.</au><au>Miguel, Sónia P.</au><au>Correia, Ilídio J.</au><au>Silva, Abílio P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites</atitle><jtitle>Ceramics international</jtitle><date>2019-05-01</date><risdate>2019</risdate><volume>45</volume><issue>7</issue><spage>8195</spage><epage>8203</epage><pages>8195-8203</pages><issn>0272-8842</issn><eissn>1873-3956</eissn><abstract>The biofunctionalization of metal implants with bioactive ceramics arises as an appealing strategy for promoting their osseointegration, without impairing implants’ good mechanical resistance. In this work, biocomposites of hydroxyapatite - CaZrO3 were obtained by rate controlled sintering and their microstructure, mechanical properties, biological as well as the effect of stoichiometric calcium zirconate dopant on the decomposition of HA were analysed. The results obtained showed that the addition of CaZrO3 stabilizes the hydroxyapatite at least up to 1300 °C and inhibits the appearance of the α- and β-TCP phases. Moreover, the mechanical properties of the hydroxyapatite were improved with 10 wt% of CaZrO3, despite the increase of porosity. The in vitro assays demonstrated that the biocomposites were biocompatible, since they favoured human osteoblast cells adhesion and proliferation. All the data obtained emphasize the potential of these biocomposites for the aimed biomedical application.</abstract><cop>Italy</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.ceramint.2019.01.122</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-8842 |
| ispartof | Ceramics international, 2019-05, Vol.45 (7), p.8195-8203 |
| issn | 0272-8842 1873-3956 |
| language | eng |
| recordid | cdi_osti_scitechconnect_1636463 |
| source | Elsevier ScienceDirect Journals |
| subjects | Bioactivity Calcium zirconate Ceramic biocomposites Hydroxyapatite Mechanical properties |
| title | Microstructural, mechanical and biological properties of hydroxyapatite - CaZrO3 biocomposites |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T12%3A24%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microstructural,%20mechanical%20and%20biological%20properties%20of%20hydroxyapatite%20-%20CaZrO3%20biocomposites&rft.jtitle=Ceramics%20international&rft.au=Vassal,%20Mariana%20F.&rft.date=2019-05-01&rft.volume=45&rft.issue=7&rft.spage=8195&rft.epage=8203&rft.pages=8195-8203&rft.issn=0272-8842&rft.eissn=1873-3956&rft_id=info:doi/10.1016/j.ceramint.2019.01.122&rft_dat=%3Celsevier_osti_%3ES0272884219301270%3C/elsevier_osti_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=S0272884219301270&rfr_iscdi=true |