Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’‐Reductases with Photoredox Catalysts

Flavin‐dependent ‘ene’‐reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2020-06, Vol.59 (26), p.10484-10488
Hauptverfasser:	Nakano, Yuji, Black, Michael J., Meichan, Andrew J., Sandoval, Braddock A., Chung, Megan M., Biegasiewicz, Kyle F., Zhu, Tianyu, Hyster, Todd K.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - chemistry 2,2'-Dipyridyl - radiation effects Alkenes biocatalysis Catalysis - radiation effects Catalysts Density Functional Theory enantioselectivity Enzymes Flavin Flavoproteins - chemistry heteroaromatic reduction Hydrogen storage Hydrogenation Light Models, Chemical Nostoc - enzymology Organometallic Compounds - chemistry Organometallic Compounds - radiation effects Oxidation-Reduction Oxidoreductases Acting on CH-CH Group Donors - chemistry photoenzymatic reaction Photoredox catalysis Pyridines Pyridines - chemistry Reductases Reduction Stereoselectivity Vinyl Compounds - chemistry ‘ene’-reductase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!