Muscone suppresses inflammatory responses and neuronal damage in a rat model of cervical spondylotic myelopathy by regulating Drp1‐dependent mitochondrial fission

Cervical spondylotic myelopathy (CSM) is a common cause of disability with few treatments. Aberrant mitochondrial dynamics play a crucial role in the pathogenesis of various neurodegenerative diseases. Thus, regulation of mitochondrial dynamics may offer therapeutic benefit for the treatment of CSM....

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Veröffentlicht in:	Journal of neurochemistry 2020-09, Vol.155 (2), p.154-176
Hauptverfasser:	Zhou, Long‐yun, Yao, Min, Tian, Zi‐rui, Liu, Shu‐fen, Song, Yong‐jia, Ye, Jie, Li, Gan, Sun, Yue‐li, Cui, Xue‐jun, Wang, Yong‐jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal products Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Apoptosis Apoptosis - drug effects Cell activation Central nervous system diseases cervical spondylotic myelopathy Compression Compression tests Cycloparaffins - pharmacology Cytokines Cytokines - antagonists & inhibitors Cytokines - biosynthesis Damage Drp1 Dynamin Dynamins - drug effects Dynamins - genetics Inflammasomes Inflammation Locomotion Macrophage Activation - drug effects Male Microglia - drug effects Mitochondria Mitochondria - drug effects mitochondrial dynamics Morphology muscone Neurodegenerative diseases Neurons Neurons - pathology Neuroprotection NLRP3 inflammasome Pathogenesis Proteins Pyrin protein Rats Rats, Sprague-Dawley Reactive oxygen species Spinal cord Spinal Cord Compression - pathology Spondylosis - drug therapy Spondylosis - pathology Spondylosis - physiopathology Tubulin
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