Kinetic Understanding of N 2 Reduction versus H 2 Evolution at the E 4 (4H) Janus State in the Three Nitrogenases

The enzyme nitrogenase catalyzes the reduction of N to ammonia but also that of protons to H . These reactions compete at the mechanistically central 'Janus' intermediate, denoted E (4H), which has accumulated 4e /4H as two bridging Fe-H-Fe hydrides on the active-site cofactor. This state...

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Veröffentlicht in:	Biochemistry (Easton) 2018-10, Vol.57 (39), p.5706-5714
Hauptverfasser:	Harris, Derek F, Yang, Zhi-Yong, Dean, Dennis R, Seefeldt, Lance C, Hoffman, Brian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Azotobacter vinelandii - enzymology Biochemistry & Molecular Biology Catalysis Enzyme Assays Hydrogen - chemistry Iron - chemistry Kinetics Molybdenum - chemistry Nitrogen - chemistry Nitrogenase - chemistry Nitrogenase - classification Nitrogenase - isolation & purification Oxidation-Reduction Vanadium - chemistry
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